Background: Chronic musculoskeletal pain (CMP) disorders, including fibromyalgia, osteoarthritis, and chronic low back pain, are prevalent conditions that result in substantial disability, psychological distress, and reduced quality of life (QoL). Emerging evidence identifies central sensitization (CS), characterized by heightened responsiveness of the central nervous system to nociceptive stimuli, as a key mechanism in the persistence and amplification of pain. However, the broader biopsychosocial impact of CS in a single integrated framework remains underexplored.
Objectives: This study aimed to investigate the relationship between central sensitization and disability, sleep disturbance, depression, and quality of life in individuals with CMP. Additionally, it assessed whether demographic factors age, sex, and pain duration moderate these relationships. Methods: A cross-sectional analysis was conducted on 150 participants aged 25–75 years with chronic musculoskeletal pain for ≥3 months. Participants completed the validated Gujarati versions of the Central Sensitization Inventory (CSI-G), RolandMorris Disability Questionnaire (RMDQ-G), Pittsburgh Sleep Quality Index (PSQI-G), Patient Health Questionnaire-9 (PHQ-9), and Short Form-12 (SF-12) for physical and mental QoL. Correlation and regression analyses were performed using SPSS v20.0, with moderation analyses evaluating the demographic influences.
Results: Twenty percent of the participants exhibited clinically significant CS and were predominantly female. The CSI-G scores were significantly correlated with increased disability (ρ = 0.530), poor sleep quality (ρ = 0.363), higher depression (ρ = 0.656), and reduced QoL (SF-12 PCS: ρ = -0.467; MCS: ρ = -0.406) (all p < 0.001). Regression analysis identified depression, disability, sleep quality, pain duration, and sex as the significant predictors of CS. Age moderated the CS–disability link, while longer pain duration intensified the CS–depression association.
Conclusion: Central sensitization is a major contributor to functional, psychological, and quality of life impairments in CMP.These findings emphasize the need for multidimensional personalized interventions targeting central mechanisms, particularly in females and patients with prolonged pain.Routine CS screening and integrated management strategies may improve the outcomes and enhance the overall well-being of the population.
Original Article
English
P. 211-221