Background: The gut-brain axis (GBA) is a bidirectional communication network between the central nervous system (CNS) and enteric nervous system that influences digestion, emotion, cognition, and pain perception through neural, hormonal, immune, and microbial pathways. Central sensitization (CS), characterized by amplified CNS nociceptive signaling, intersects with GBA dysregulation, exacerbating chronic pain conditions such as irritable bowel syndrome (IBS) and fibromyalgia. Visceral mobilization (VM), a manual therapy that restores organ mobility, can modulate these pathways. Objective: This narrative review synthesizes recent literature on GBA mechanisms, central sensitization pathophysiology, and the therapeutic potential of visceral mobilization in chronic pain management. Key Findings: This review explores the GBA mechanisms, including microbiotaderived metabolites, such as short-chain fatty acids, which reduce inflammation and support neuroprotection. The pathophysiology of CS involves N-methyl-Daspartate receptor (NMDA) receptor activation, glial inflammation, and neural plasticity, with significant interplay with GBA. Dysbiosis heightens visceral
hypersensitivity via cytokine signaling and hypothalamic-pituitary-adrenal (HPA) axis disruption. Evidence for VM is mixed but promising, showing benefits in low back pain and IBS by improving motility and autonomic tone, and potentially alleviating CS through reduced afferent input. Clinical Implications: The Physiotherapists should integrate VM with exercise and dietary education to address comorbid gut pain disorders holistically. Understanding this nexus empowers clinicians to refine their assessments and interventions, thereby enhancing the outcomes of chronic visceral pain management. Conclusion: Further randomized trials are required to validate these findings and establish evidence-based protocols for visceral mobilization in physiotherapy.
Review Article
English
P. 221-229