Rahul A. Mehta, Head of Department, Department of Forensic Medicine, Shri MP Shah Medical College, Jamnagar, Gujarat,, India
Ina Patel 2nd Year Resident, Department of Forensic Medicine, Shri M P Shah Medical College, Jamnagar, Gujarat, India
Kuldip Teraiya 2nd Year Resident, Department of Forensic Medicine, Shri M P Shah Medical College, Jamnagar, Gujarat, India
Address for correspondence: Rahul A. Mehta,, Head of Department, Department of Forensic Medicine, Shri MP Shah Medical College, Jamnagar, Gujarat,, India E-mail: rahul_mehta626@yahoo.com
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Patel I, Teraiya K, Mehta RA. Study of Incidence and Severity of Coronary Artery Stenosis at Autopsy. Indian J Forensic Med Pathol. 2025;18(3):159-64.
Timeline
Received : May 09, 2025
Accepted : July 23, 2025
Published : September 30, 2025
Abstract
Backgrounds: The occurrence of sudden cardiac death (SCD) has been continuously rising globally. Identification of modifiable risk factors may help reduce the incidence of sudden cardiac death. Aims: This study aimed to evaluate the incidence, associated risk factors, myocardial ischemic changes, and the specific arterial involvement in individuals who died due to a cardiac event. Material and method: The study was conducted at the Department of Forensic Medicine, Shri M. P. Shah Govt. Medical College, Jamnagar, from January 2023 to
December 2023. A total of 110 cases of sudden death were included in the study. The heart was examined in these cases for both gross and myocardial analysis. Results: Left anterior descending artery (27.27%) was the most common site of stenosis, followed by left main artery (13.63%). The main feature was softening
(8.18%) of myocardium, followed by hyperemia (4.54%) and myocardial fibrosis (3.63%) in the cases showing gross changes of ischemia. Conclusion: Sudden death caused by acute myocardial infarction mainly affects
middle-aged individuals, with an increasing trend in younger people. The most common artery affected by stenosis was the left anterior descending artery, with most cases showing grade-3 or grade-4 stenosis. The left lateral wall is the most common site of infarction. Hypertension, Diabetes, nicotine consumption and drinking habits are the major risk factors. Nicotine and drinking habits can accelerate the development of coronary artery stenosis.
References
1. Reddy K.S.N. The Essentials of Forensic Medicine and Toxicology. 29th ed. Hyderabad: K. Suguna Devi; 2010: 101-103, 136.
2. Ahmad M., Afzal S., Malik I.A., Mustaq S., Mubarik A. An autopsy study of sudden cardiac death. JPMA 2005; 55: 149-155.
3. Kannel W.B., Thomas H.E. Jr. Sudden coronary death: The Framingham Study. Ann NY Acad Sci 1982; 382: 3-20.
4. Kannel W.B., Cupples L.A., D’Agostino R.B. Sudden death risk in overt coronary heart disease: the Framingham Study. Am Heart J 1987; 113: 799-804.
5. Dzavick V. The need for revascularization procedure will remain the same for increase in next decade. Canadian J Cardiol 1998; 14: 27-31. 6. Park K. Park’s Texbook of Preventive and Social Medicine. 17th ed. Jabalpur: Banarasidas Bhanot; 2002: 273-282.
6. Park K. Park’s Texbook of Preventive and Social Medicine. 17th ed. Jabalpur: Banarasidas Bhanot; 2002: 273-282.
8. Gupta S., Panchal R., Sondarva D. An approach to sudden natural deaths in medicolegal autopsies at Karamsad, Gujrat. J Indian Acad Forensic Med 2011; 33(1): 30-32.
9. Sharma R., Rani Y., Aggarwal K., Murari A. Postmortem study to detect ischemic changes of heart in central Delhi. J Forensic Medicine and Toxicology 2007; 24(2): 26-29.
10. Gohel H., Desai N., Tripathi S., Gupta B.D., Santwani P. Post mortem study of heart in cases of sudden cardiac death using acridine orange fluorescence and haematoxylin and eosin stain. Indian Journal of Medicine and Healthcare 2012; 1(5): 115-123.
11. Strong J.P., Malcom G.T., McMaham C.A., Tracy R.E., Newman W.P., Herderick E.E. Prevalence an extent of atherosclerosis in adolescents and young adults. JAMA 1999; 281: 727-735.
12. Yazdi et al. Prevalence of atherosclerotic plaques in autopsy cases with noncardiac death. Iranian J Pathology 2009; 4(3): 101-104.
13. Garg M., Aggarwal A.D., Katariya S.P. Coronary atherosclerosis and myocardial infarction an autopsy study. J Indian Acad Forensic Med 2011; 33(1): 39-42.
14. Strong J.P., McGill HC. The natural history of coronary atherosclerosis. Am J Pathol 1962; 40: 37-49.
15. Chen X., Huang G. A pathological study of sudden coronary death in china: report of 89 autopsy cases. Foren Sci Intl 1992; 57: 129-137.
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
About this article
Cite this article
Patel I, Teraiya K, Mehta RA. Study of Incidence and Severity of Coronary Artery Stenosis at Autopsy. Indian J Forensic Med Pathol. 2025;18(3):159-64.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.