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Relevance of Mast Cell Variations in Uterocervical Lesions

Meghana P., Gayathri M.N., Sruthi Madhusudanan

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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

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Indian Journal of Pathology: Research and Practice 12(3):p 89-93, July-September 2023. | DOI: https://doi.org/10.21088/ijprp.2278.148X.12323.1

How Cite This Article:

Gayathri M.N., Meghana P., Sruthi Madhusudanan/Relevance of Mast Cell Variations in Uterocervical Lesions/Indian Journal of Pathology: Research and Practice 2023;12(3) 89–93.

Timeline

Received : July 25, 2023         Accepted : August 30, 2023          Published : September 30, 2023

Abstract

Context: Mast cells are a heterogenous group of immune cells involved in a variety of biological processes. The presence of mast cells intumours has been described as an evidence of a host immunologic anti-tumor response, and their abundance as an indicator of a favourable prognosis. However, it is also stated to be extremely closely associated with angiogenesis and tumour invasion. Because the literature on mast cells in uterocervical lesions is limited, the current study seeks to look for changes in mast cells in some of the common uterocervical lesions and their potential implications in diagnosis and prognosis. Aims: To study the mast cell density in various neoplastic and non-neoplastic lesions of uterocervical lesions. Settings and Design: Prospective study done over a period of one year in a tertiary care hospital. Methods and Material: Hysterectomy specimens received in the department of pathology a tertiary care hospital, were stained with H&E and toluidine blue for the identification of mast cell. Statistical Analysis used: For categorical variables, frequencies, proportions, Chi square test for proportion is used and for continuous variables, mean, standard deviation, independent test will be used. Results: The most common neoplastic and non-neoplastic lesions were leiomyoma and chronic cervicitis respectively and the highest mean mast cell count was more in non-neoplastic lesions. Conclusions: The study revealed that the mast cell count decreased progressively from non-neoplastic and benign to malignant lesions, implying that the mast cell count appeared to be inversely related to the degree of dysplasia and thus may be an additional diagnostic tool in different uterocervical lesions and may act as a good prognostic indicator of the lesions' benign nature.

References

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Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.

About this article

Cite this article

Gayathri M.N., Meghana P., Sruthi Madhusudanan/Relevance of Mast Cell Variations in Uterocervical Lesions/Indian Journal of Pathology: Research and Practice 2023;12(3) 89–93.

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Received Accepted Published
July 25, 2023 August 30, 2023 September 30, 2023
DOI: https://doi.org/10.21088/ijprp.2278.148X.12323.1

Keywords

Mast cellsUterocervical lesionsNeoplasticNon-neoplastic

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Timeline

Received July 25, 2023
Accepted August 30, 2023
Published September 30, 2023

licence

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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