Anandraj Vaithy. K Professor, Department of Pathology, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth University (Deemed), Puducherry 607402, India
C. Naveen Selva Post Graduate Student, Department of Pathology, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth University (Deemed), Puducherry 607402, India
Shanmugasamy K. Professor, Department of Pathology, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth University (Deemed), Puducherry 607402, India
Kavitamani K. Assistant Professor, Department of Pathology, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth University (Deemed), Puducherry 607402, India
Sowmya null Professor & HOD, Department of Pathology, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth University (Deemed), Puducherry 607402, India
Address for correspondence: Anandraj Vaithy. K, Professor, Department of Pathology, Mahatma Gandhi Medical College & Research Institute, Sri Balaji Vidyapeeth University (Deemed), Puducherry 607402, India E-mail: kanandrv@gmail.com
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
C. Naveen Selva, Shanmugasamy K., Sowmya, et al./Adenofibroma of Cervix: An Unusual Presentation/Indian Journal of Pathology: Research and Practice 2023;12(3) 111–113.
Timeline
Received : July 19, 2023
Accepted : August 30, 2023
Published : September 30, 2023
Abstract
Papillary Adenofibroma is an extremely rare condition and is benign biphasic tumor composed of epithelial and mesenchymal components. It occurs more often in extra uterine sites and in the female genital tract it is known to occur more common in the endometrium. The presence of this condition in cervical region is extremely rare and even the available cases show young to middle age predilection. In the present case report we had a sixty year old post menopausal female who came with the complaints of bleeding per vaginum for five days and complaints of burning micturition with a provisional diagnosis of endocervical polyp clinically. Radiologically imaging was suggestive of papillary neoplasm. Biopsy studied showed features of lobulated papillae covered by bland endocervical epithelium with a foci showing squamous metaplasia features suggestive of benign papillary adenofibroma of cervix and reiterated with special stain as well. It is a rare tumor having high chance of recurrence, with a very low incidence rate and account for less than 10% of uterine adenofibromas. Usually this condition presents as broad based polypoidal mass with abnormal vaginal bleeding. They need a differential diagnosis with Adenomyoma, Adenosarcoma and Carcinosarcoma which share many common features on histology.
References
1. Haberal A, Cil AP, Gunes M, Cavusoglu D. Papillary adenofibroma of the cervix: a case report. Ultrasound Obstet Gynecol. 2005;26(2):186–7.
2. Li BB, Zheng YH, Chen QY, Guo ZQ. Cervical adenofibroma without clinical symptoms: report of a rare case. J Int Med Res. 2022 Sep; 50 (9):3000605221125525.
3. Ishiko O, Sumi T, Ueda K, Kawamura N, Ogita S. Uterine cervical adenofibroma associated with Turner’s syndrome in a young woman. Arch Gynecol Obstet. 2002 Nov;267(1):49–50.
4. Abell MR. Papillary adenofibroma of the uterine cervix. Am J Obstet Gynecol. 1971 Aug 1;110(7):990–3.
5. Fratini D, Cavaliere A. Papillary adenofibroma of the uterine cervix. A case report. Pathologica. 1996 Apr;88(2):135–6.
6. Chen L, Chi Y, Chen Y. Recurrent cervical adenofibroma progressing to adenosarcoma: a rare case report. Ginekol Pol. 2023 Jul 11;VM/OJS/J/93728.
7. Navada HM, Bhat BPR, Ramani G, Gatty RRC, Jayaprakash CS. Unusual Presentation of Rare Case of Papillary Adenofibroma of Cervix in a Young Woman. Case Rep Oncol Med. 2012 Feb 2; 2012:e914642.
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
About this article
Cite this article
C. Naveen Selva, Shanmugasamy K., Sowmya, et al./Adenofibroma of Cervix: An Unusual Presentation/Indian Journal of Pathology: Research and Practice 2023;12(3) 111–113.
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.