Abstract

Gastrointestinal involvement of endometriosis has been found in 6%- 10% of reproductive age group women and exclusive localization on the ileum is very rare (1%-7%). Endometriosis is characterized by the presence of endometrial tissue consisting of glands and/or stroma located outside the uterus. When the terminal ileum is affected by endometriosis, the entity distinction from other diseases of the ileocecal region is difficult in terms of clinical presentation, symptomatology and radiological appearance. Histological assessment after resection of the involved small bowel segment in the three patients shows a final diagnosis of ileal endometriosis with confirmation by Immunohistochemistry which shows ER, PR and CD10 positive.

• 1.   Mehmood S, Zhao S, Ain Q, Van Dellen J, Beggan C. Endometriosis of the Small Bowel: A Diagnostic Enigma. Cureus. 2021 Jun 8;13(6).
• 2.   Zepeda MR, Win SK. A Rare Case of Endometriosis of the Small Bowel. Case reports in pathology. 2021 May 8;2021.
• 3.   Keane TE, Peel AL. Endometrioma. An intraabdominal troublemaker. Dis Colon Rectum 1990; 33: 963-965.
• 4.   De Ceglie A, Bilardi C, Blanchi S, Picasso M, Di Muzio M, Trimarchi A, Conio M. Acute small bowel obstruction caused by endometriosis: a case report and review of the literature. World journal of gastroenterology: WJG. 2008 Jun 7;14(21):3430.
• 5.   Bacalbasa N, Balescu I, Filipescu A. Ileocecal obstruction due to endometriosis–A case report and literature review. in vivo. 2017 Sep 1;31(5):999-1002.
• 6.   Alabbas H, Awidah T, Alhallaq O, Babiker T. Small bowel endometriosis; a case report and review of literature. Annals of Medicine and Surgery. 2019 Nov;47:24.
• 7.   Terro JJ, Jammoul KM, Lakkis RS, Al Raishouni MA, Mneimneh M, Abtar HK. Ileocecal endometriosis mimicking Crohn’s disease and causing acute small bowel obstruction: A case report and review of literature. Int J Case Rep Images. 2020;11(1).
• 8.   Foulon A, Pichois R, Sabbagh C, Fumery M. Bowel endometriosis mimicking crohn disease. Inflammatory Bowel Diseases. 2021 Mar;27(3):e26-7.
• 9.   Chiaffarino F, Cipriani S, Ricci E, Roncella E, Mauri PA, Parazzini F, Vercellini P. Endometriosis and inflammatory bowel disease: A systematic review of the literature. European Journal of Obstetrics & Gynecology and Reproductive Biology. 2020 Sep 1;252:246-51.
• 10.   Zepeda MR, Win SK. A Rare Case of Endometriosis of the Small Bowel. Case reports in pathology. 2021 May 8;2021.
• 11.   Syed ImtiyazHussain, Gulshan Akhter, Baba Iqbal Khaliq and Ruby reshi. Ileocecal endometriosis presenting as intestinal obstruction. International Journal of Current Research 2016;8:34161-34163.
• 12.   Karaman K, Pala EE, Bayol U, Akman O, Olmez M, Unluoglu S, Ozturk S. Endometriosis of the terminal ileum: a diagnostic dilemma. Case Reports in pathology. 2012 Jan 1;2012.
• 13.   Bacanakgil BH, Güngör ES, Kaban I, İlhan G, Sarı S. Intestinal endometriosis: Clinical reflections.
• 14.   Habib N, Centini G, Lazzeri L, Amoruso N, El Khoury L, Zupi E, Afors K. Bowel endometriosis: current perspectives on diagnosis and treatment. International journal of women's health. 2020;12:35.

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