Abstract

Background & Objectives: Platelet transfusion reduces mortality from hemorrhage in patients with thrombocytopenia. Platelet transfusions are given prophylactically or therapeutically for managing patient with various platelet consumptive or destructive disorders. This study evaluates the effect of platelet transfusion over the count and parameters of platelets. The objective of this study is to compare the Platelet count, Mean Platelet Volume (MPV) and Platelet Distribution Width (PDW) before and after platelet transfusion. Materials and Methods: The platelet parameters of 202 samples with thrombocytopenia, demographic variables including gender, clinical details including indication for platelet transfusion, blood group, Platelet count, MPV, PDW before and after transfusion and additional details such as critical illness, transfusion reaction, stay in ICU etc, were noted. Descriptive statistics such as mean were calculated for descriptive variables such as difference in platelet count, MPV, PDW before and after transfusion. Results: The rise in platelet count with one unit of platelets was approximately 40000/µL and that with 12 units was 1,00,000/µL.The rise in MPV with one unit of platelets was approximately 2 fL and that with 12 units was approximately 1 fL. The mean rise in PDW after platelet transfusion ranged from 1.2 to 1.8. Conclusion: Platelet count, MPV and PDW increase after platelet transfusion. The increase in platelet count is disproportionate to the number of units transfused.

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