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Indian Journal of Forensic Medicine and Pathology 14(4):p 819-824, October – December 2021. | DOI: https://doi.org/10.21088/ijfmp.0974.3383.14421.6
Original Article
Study of the Impact of Leucocyte Reduction on the Coagulation Factors in Fresh Frozen Plasma
Femela Muniraj null, Vijayashree Raghavan1 null, Femela Muniraj null
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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Indian Journal of Forensic Medicine and Pathology 14(4):p 819-824, October – December 2021. | DOI: https://doi.org/10.21088/ijfmp.0974.3383.14421.6
How Cite This Article:
How to cite this article Vijayashree Raghavan, Femela Muniraj/Study of the Impact of Leucocyte Reduction on the Coagulation Factors in Fresh Frozen Plasma /Indian Journal of Forensic Medicine and Pathology/2021;14(4):819-824
Timeline
Received : October 02, 2021
Accepted : October 20, 2021
Published : December 30, 2021
Abstract
Introduction: Plasma transfusion is required to arrest or prevent bleeding, for various congenital and acquired cases of coagulopathies such as inherited factor deficiencies, disseminated intravascular coagulation, liver disease, post major trauma, etc. Leukocyte reduced blood components are indicated to prevent the febrile nonhemolytic transfusion reactions, Human Leukocyte Antigen (HLA) alloimmunization, transmission of infections such as cytomegalovirus (CMV), and adverse transfusion reactions due to storage lesion. In the present study, the effect of plasma filtration on eight coagulation factors viz. fibrinogen, factors II, V, VII, VIII, IX, X and XI has been studied. Materials
and Methods: The plasma separated from the whole blood donation from each of 25 donors was separated into two aliquots. Group-1 included unfiltered fresh frozen plasma; group-2 included fresh frozen plasma which was subjected to pre-storage leukocytereductionbyfiltration.ThelevelsofthecoagulationfactorsFibrinogen,II,V, VII, VIII, IX, X, XI were estimated in each sample in both the groups. Results: There was no statistically significant difference in the levels of any of the coagulation factors included in this study, between the unfiltered and the leukocyte reduced plasma. Group O positive individuals were found to have higher levels of all the coagulation factors.
Conclusion: Filtration of plasma has no effect on the coagulation factors. This is the first study where the effect of plasma filtration on eight coagulation factors has been studied. Blood group O positive individuals were found to have higher levels of all the eight coagulation factors.
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Cite this article
How to cite this article Vijayashree Raghavan, Femela Muniraj/Study of the Impact of Leucocyte Reduction on the Coagulation Factors in Fresh Frozen Plasma /Indian Journal of Forensic Medicine and Pathology/2021;14(4):819-824
Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
| Received | Accepted | Published |
|---|---|---|
| October 02, 2021 | October 20, 2021 | December 30, 2021 |
DOI: https://doi.org/10.21088/ijfmp.0974.3383.14421.6
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Timeline
| Received | October 02, 2021 |
| Accepted | October 20, 2021 |
| Published | December 30, 2021 |
licence
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
