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Indian Journal of Forensic Medicine and Pathology 14(4):p 825-830, October – December 2021. | DOI: https://doi.org/10.21088/ijfmp.0974.3383.14421.7
Original Article
Effect of formalin fixation on DNA: A Time-Based Approach
Neeharika Srivastava null, Jyoti Gullaiya1 null, Naresh Kumar null, 2 Neeharika Srivastava3 null
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Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Indian Journal of Forensic Medicine and Pathology 14(4):p 825-830, October – December 2021. | DOI: https://doi.org/10.21088/ijfmp.0974.3383.14421.7
How Cite This Article:
How to cite this article Jyoti Gullaiya, Naresh Kumar, Neeharika Srivastava/Effect of formalin fixation on DNA: A Time-Based Approach/Indian Journal of Forensic Medicine and Pathology/2021;14(4):825-830
Timeline
Received : October 02, 2021
Accepted : October 20, 2021
Published : December 30, 2021
Abstract
Introduction: Tissue preservation is important. From it forensic scientist may extract sufficient DNA for profiling. The most commonly used preservative found in the literature is formalin. However, it causes severe side-effects on its users as well as the environment; we need to find its replacement.
Method: This study examined whether formalin could preserve soft tissues (fresh) stored at 4°C for 100 days and how DNA can be extracted from it. Qualification and Quantification of the presevred samples were done.
Result: The results revealed that tissues preserved in formalin failed to generate sufficient quantity of DNA for profiling whereas tissues preserved in normal saline did so.
Conclusion: The study concluded that there is a need to find an alternative to formalin which can preserve the tissue samples well and enable DNA profiling
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Cite this article
How to cite this article Jyoti Gullaiya, Naresh Kumar, Neeharika Srivastava/Effect of formalin fixation on DNA: A Time-Based Approach/Indian Journal of Forensic Medicine and Pathology/2021;14(4):825-830
Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
| Received | Accepted | Published |
|---|---|---|
| October 02, 2021 | October 20, 2021 | December 30, 2021 |
DOI: https://doi.org/10.21088/ijfmp.0974.3383.14421.7
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Timeline
| Received | October 02, 2021 |
| Accepted | October 20, 2021 |
| Published | December 30, 2021 |
licence
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
