Neha Sharma GIHPB Fellow, Department of Histopathology, Lilavati Hospital and Research Centre, Mumbai 400050, Maharashtra, India
Asha Mary George Consultant, Department of Histopathology, Lilavati Hospital and Research Centre, Mumbai 400050, Maharashtra, India
Anshika Rai Clinical Assistant, Department of Histopathology, Kokilaben Dhirubhai Ambani Hospital, Mumbai 400061, Maharashtra, India
Address for correspondence: Neha Sharma, GIHPB Fellow, Department of Histopathology, Lilavati Hospital and Research Centre, Mumbai 400050, Maharashtra, India E-mail: neha3336@gmail.com
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
Asha Mary George, Anshika Rai, Neha Sharma. Primary Neuroendocrine Tumour of Extrahepatic Bile Duct: A Rarity. Ind J
Pathol: Res Pract. 2023;12(4) 143–146.
Timeline
Received : October 22, 2023
Accepted : November 25, 2023
Published : December 30, 2023
Abstract
Extrahepatic bile duct Neuroendocrine Tumour (NET) is uncommon, and hence a preoperative diagnosis is rare. The definite diagnosis depends on post-operative histopathology examination and immunohistochemistry studies. Complete excision of the lesion is considered as a curative treatment. We report a case of 39 year old male who presented with obstructive
jaundice and imaging suggested Cholangiocarcinoma involving the hepatic ducts. He underwent a right hepatectomy and cholecystectomy with hepatoduodenal lymphadenectomy. The histopathological examination revealed a Neuroendocrine Tumour.
References
1. Noronha YS, Raza AS. Well-differentiated neuroendocrine (carcinoid) Tumours of the extra hepatic biliary ducts. Arch Pathol Lab Med 2010; 134 (7): 1075–1079.
2. T. Colak, Carcinoid Tumour of the Common Bile Duct: Report of a Case and a Review of the Literature Carcinoid Tumour of the Common Bile Duct: Report of a Case and a Review of, 2006, pp. 1–5, https://doi.org/10.1080/ 00015458.2006.11679850 (February).
3. A. Jethava, V. Muralidharan, T. Mesologites, E. Stoica-Mustafa, C.A. Dasanu, H. Medicine, Case report an unusual presentation of a carcinoid tumour of the common bile duct JOP. J. Pancreas (online) 2013 Jan 10, 14 (1) (2013) 85–87.
4. K. Hosoda, et al., Neuroendocrine tumour of the common bile duct, Surgery 2016;160(2) (2016) 525-526.
5. N. Michalopoulos, et al., Neuroendocrine tumours of extrahepatic biliary tract,Pathol. Oncol. Res. 2014 Oct;20(4):765–775.
6. Nagtegaal ID, Odze RD, Klimstra D, Paradis V, Rugge M, Schirmacher P, Washington KM, Carneiro F, Cree IA: WHO Classification of Tumours Editorial Board. The 2019 WHO classification of tumours of the digestive system. Histopathology 2020 Jan;76(2):180-188.
7. Taj R, Perez S, Jih LJ, Huynh C, Berumen J, Bouvet M. Primary extrahepatic biliary neuroendocrine tumour: a case report. J Surg Case Reports. 2023 May 27;2023(5):1-3.
8. Hubert C, Sempoux C, Berquin A, Deprez F, Jamar F, Giqot JF. Bile duct carcinoid tumours: an uncommondisease but with a good prognosis? Hepato-Gastroenterol. 2005; 52: 1042–7.
9. Safwan, M., Vij, M., Govil, S. et al. Well-Differentiated Neuroendocrine Tumour of the Extrahepatic Bile Duct: a Case Report with Review of Literature. J GastrointestCanc 47, 93–99 (2016).
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
About this article
Cite this article
Asha Mary George, Anshika Rai, Neha Sharma. Primary Neuroendocrine Tumour of Extrahepatic Bile Duct: A Rarity. Ind J
Pathol: Res Pract. 2023;12(4) 143–146.
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
Description: A – Tumour cells arranged in lobules (H&E stain 40x), B – Tumour cells arranged in nests, islands, trabeculae, and organoid pattern (H&E stain 100x), C - Perineural and intraneural invasion (H&E stain 100x), D – Tumour cells exhibiting round to ovoid nuclei with salt and pepper chromatin (H&E stain 400x)
Heading
Description: On Immunohistochemistry, the tumour is positive for Synaptophysin (A), Chromogranin (B), CK (C) and Ki67 showed 8 to 9% proliferation index (D).
Heading
Description: Classification and grading criteria for neuroendocrine neoplasms (NENs) of the GI tract and hepatopancreatobiliary organs.