Abstract

Aim: This investigation was carried out to examine the diagnostic utility and value of bone marrow aspirate and biopsy in different hematological illnesses, as well as the part that both procedures play an important role in obtaining an accurate diagnosis when carried out in tandem. Methods and Material: In order to link the results of bone marrow aspiration and biopsy in diverse hematological disorders, the pathology department at BGS GIMS undertook the current prospective investigation. Bone marrow evaluation using both marrow biopsy and bone marrow aspirate was performed on 106 participants in this study. Cases without or with insufficient bone marrow aspirate for an opinion were not included in the analysis. Results: The age range of 31 to 40 years old was the most frequently observed, with a male majority. The most frequent finding was nutritional anemia, among those with nutritional anaemia, the most frequent finding was megaloblastic maturation (33.9%), micronormoblastic maturation (13.2%), and megaloblastic and micronormoblastic maturation (15.2%). Acute leukemia was 1.8% and chronic leukemia was 2.8%. Twelve cases (11.32%) of plasma cell dyscrasia were found in our study. Aplastic anemia, prostatic adenocarcinoma carcinoma metastasis, immune thrombocytopenic purpura (ITP), hematolymphoid malignancy, and myelofibrosis were among the other cases. \ Conclusion: Both the bone marrow biopsy and aspiration are complementary procedures that aid in the identification of a range of haematological disorders. When combined with a clinical examination and auxiliary tests, bone marrow examination is a valuable diagnostic tool for the diagnosis of a variety of haematological illnesses.

• 1.   Firkin F, Chesterman C, Rush B, Pennigton D. De Gruchy’s Clinical Haematology in Medical Practice, 5th Ed. John Wiley & Sons; 2008.
• 2.   Shubhangi Agale et al. International Journal of Medical Reviews and Case Reports (2021) 5(13):24-3.
• 3.   Kaur M, Singh Rana AP, Kapoor S, Puri A. Diagnostic Value of Bone Marrow Aspiration and Biopsy in Routine Hematology Practice. Journal of Clinical and Diagnostic Research: JCDR. 2014;8(8):FC13- FC16. doi:10.7860/ JCDR/2014/9823.4760.
• 4.   Mehra, Rani B, Singh J, Paul S, Kumar P, Goyal S. Diagnostic utility of bone marrow aspiration, imprint and biopsy in evaluation of various haematological disorders. Int. J. Curr. Res. Med. Sci. 2018; 4(1): 28-36.
• 5.   Atla Bhagya Lakshmi; Anem Venkatalakshmi; Dasari A Prospective study of bone marrow in haematological disorders. International Journal of Research in Medical Sciences, (S.l.), v. 3, n. 8, p. 1917-1921, Jan. 2017. ISSN 2320-6012.
• 6.   Gohil M, Rathod K. Bone Marrow Aspiration Cytology Study in a Tertiary Care Center, Gujarat, India. Int J Sci Stud 2018; 5(10):11-14.
• 7.   Tilak V, Das S, Bundhun S. Value of Bone Marrow Imprint Smears in Early Diagnosis ofBone Marrow Pathologies. Journal of Clinical and Diagnostic Research. 2014; 8(11): 01-3.
• 8.   Chauhan S, Pradhan S, Mohanty R, Saini A. Bone marrow trephine biopsies: A single centre experience in Eastern India. Arch Med Health Sci 2017; 5:34-8.
• 9.   Charles KS, Winfield DA, Angel C, Goepel J. Audit of bone marrow aspirates and trephine biopsies in multiple myeloma – A single centre study. Clin Lab Haematology 2004; 26:403 6.
• 10.   Shefali Verma et al., Correlation between Bone Marrow Aspiration and Bone Marrow Biopsy with Imprint Smears in Hematological Disorders. 2016 Jul; 5(3):64–9. doi: 10.7860/ NJLM/2016/20880.2148.
• 11.   Thakur S, Thaker B, Kailash Singh Thaker, Afsana Anjum. Utility of bone marrow aspiration and trephine biopsy in various haematological malignancies. International Journal of Research in Medical Sciences. 2023; 11(4):1128– 35. doi:10.18203/2320-6012. ijrms20230693.
• 12.   Vijayamohanan L, Asotra S, Kumari K. Comparative utility of bone marrow aspiration and trephine biopsy in evaluation of haematological disorders. Arch Med Health Sci. 2020; 8:15-9.
• 13.   Gilotra M, Gupta M, Singh S, Sen R. Comparison of bone marrow aspiration cytology with bone marrow trephine biopsy histopathology: An observational study. J Lab Physicians. 2017; 9:182-9.

Data Sharing Statement

Funding