Devanshi Shah Junior Resident, Department of Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra,, India
Manjusha Dhawle Associate Professor, Department of Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India
Shweta Watane Assistant Professor, Department of Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India
Abhishek Muley Assistant Professor, Department of Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra,, India
Ashwini Waso Junior Resident, Department of Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra,, India
Abhishikta Misra Junior Resident, Department of Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India
Sushma Ramraje Professor and Head of Department, Department of Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra, India
Address for correspondence: Devanshi Shah, Junior Resident, Department of Pathology, Grant Government Medical College and Sir JJ Group of Hospitals, Mumbai, Maharashtra,, India E-mail: devanshi0102@gmail.com
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Manjusha D, Shweta W, Abhishek M, et al. Histopathological Study of Incidental Neoplastic Lesions in Autopsy Cases: A Retrospective Observational Study in a Tertiary Care Centre. Indian J Forensic Med Pathol. 2026;19(1):21-27.
Timeline
Received : November 05, 2025
Accepted : January 25, 2026
Published : March 30, 2026
Abstract
Context: Autopsy remains an invaluable tool in the advancement of pathological knowledge, particularly through the identification of rare or incidental neoplastic and non neoplastic lesions that may otherwise remain undetected during life. Many such findings are asymptomatic and cause no significant functional impairment.
This study aims to underscore the significance of the incidental neoplastic lesions in pathological medicolegal autopsies. Aim: To determine the spectrum of histopathological findings in neoplastic lesions identified during autopsy, whether or not they were related to the cause of death. Materials and Methods: A retrospective review of medicolegal autopsies conducted over a period of one year at a tertiary care center was performed.
Histopathological examinations were carried out and the findings were analyzed to identify neoplastic lesions.
Results: The present study consisted of a series of 303 autopsy cases from Department of Pathology in a tertiary care hospital conducted over a period of one year. The internal organs of total of 303 autopsies were sent for histopathological examination. Neoplastic lesions were identified in 4.95% of cases. Conclusion: This study has added valuable insights to the repository of rare incidental neoplastic lesions. Autopsy studies remain crucial for uncovering clinically silent yet potentially significant pathological conditions, some of which could have impacted patient management if identified antemortem.
References
1. Thurnheer R., Hoess C., Doenecke C., Moll C., Muntwyler J. Krause M. Diagnostic performance in a primary referral hospital assessed by autopsy: evolution over a ten-year period. Eur. J. Intern. Med. 2009; 20; 784-787.
2. Roulson J., Benbow E.W., Hasleton P.S. Discrepancies between clinical and autopsy diagnosis and the value of post mortem histology; a meta-analysis and review. Histopathology 2005; 47: 551-559.
3. Kuijpers CCHJ, Fronczek J., van de Goot FRW, Niessen HWM, van Diest PJ, Jiwa M. The value of autopsies in the era of high-tech medicine: discrepant ndings persist. J. Clin. Pathol. 2014; 67: 512-519.
4. Zerbini T., Singer J.M., Leyton V. Evaluation of the discrepancy between clinical diagnostic
5. Lucas S., Cooper H., Emmett S., Hargraves C. The coroner’s autopsy: do we deserve etter?.
6. Bernardi F.D.C., Saldiva P.H.N., Mauad T. Histological examination has a major impact on macroscopic necropsy diagnoses. J. Clin. Pathol. 2005: 58: 1261-1264.
7. Humez S., Delteil C., Maurage C.A. et al. Does the medical autopsy still have a place in the current diagnostic process? -year etrospective study in two French University hospitals. Forens. Sci. Med. Pathol. 2019; 15: 564-569.
8. Jurgen Ludwig, M.D. Handbook of Autopsy Practice, third edition.
9. Molina D.K., Wood L.E., Frost R.E. Is routine histopathologic examination benecial in all
10. Patel S, Rajalakshmi B.R., Manjunath G.V. Histopathologic Findings in Autopsies with Emphasis on Interesting and Incidental Findings-A Pathologist’s Perspective. J Clin Diagn Res. 2016 Nov; 10(11): EC08-EC12.
11. Mohan, Bhavya P.; Sivaraman, Lesitha; Vijayan, Surekha; Das, Aathira G. Spectrum of incidental tumors in autopsy specimens: A histopathological analysis of 797 cases. Indian Journal of Health Sciences and Biomedical Research KLEU 16(2): pp. 292-297, May–Aug 2023.
12. Pallagani L., Choudhary G.R., Himanshu P, Madduri VKS, Singh M., Gupta P., Shrivastava N., Baid G, Meenakshi R., Aasma N., Pareek P., Sanjeev M. Epidemiology and Clinicopathological Prole of Renal Cell Carcinoma: A Review from Tertiary Care Referral Centre. J Kidney Cancer VHL. 2021
13. Donato F., Tagger A., Gelatti U., Parrinello G, Boffetta P., Albertini A., Decarli A, Trevisi P., Ribero M.L., Martelli C., Porru S., Nardi G. Alcohol and hepatocellular carcinoma: the effect of lifetime intake and hepatitis virus infections in men and women. Am J Epidemiol. 2002 Feb 15; 155(4): 323-31.
14. Thakkar J.P., Dolecek T.A., Horbinski C., Ostrom Q.T., Lightner D.D., Barnholtz-Sloan J.S., Villano J.L. Epidemiologic and molecular prognostic review of glioblastoma. Cancer Epidemiol Biomarkers Prev. 2014 Oct; 23(10): 1985-96.
15. Anton-Culver H., Culver B.D., Kurosaki T., Osann K.E., Lee J.B. Incidence of lung cancer by histological type from a population-based registry. Cancer Res. 1988 Nov 15; 48(22): 6580-3. PMID: 2846154.
16. Giona S. The Epidemiology of Testicular Cancer. In: Barber N., Ali A., editors. Urologic Cancers [Internet]. Brisbane (AU): Exon Publications; 2022 Sep 12. Chapter 9.
17. Lanjewar D.N., Sheth N.S., Lanjewar S.D., Wagholikar U.L. Analysis of Causes of Death as Determined at Autopsy in a Single Institute, The Grant Medical College and Sir J. J. Hospital, Mumbai, India, Between 1884 and 1966: A Retrospective Analysis of 13 024 Autopsies in Adults. Arch Pathol Lab Med. 2020 May; 144(5): 644-649.
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
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Manjusha D, Shweta W, Abhishek M, et al. Histopathological Study of Incidental Neoplastic Lesions in Autopsy Cases: A Retrospective Observational Study in a Tertiary Care Centre. Indian J Forensic Med Pathol. 2026;19(1):21-27.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.