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Histopathological spectrum of Pulmonary Lesions: An Autopsy based study

Athira K.P, Mohit Kumar, Chaitra BE

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Indian Journal of Forensic Medicine and Pathology 16(2):p 101-106, April–June 2023. | DOI: https://doi.org/10.21088/ijfmp.0974.3383.16223.2

How Cite This Article:

Athira KP, Kumar M, Chaitra BE. Histopathological spectrum of pulmonary lesions: an autopsy based study. Indian J Forensic Med Pathol. 2023;16(2):101-106.

Timeline

Received : January 13, 2023         Accepted : April 03, 2023          Published : June 30, 2023

Abstract

Autopsy is a medical practice where post mortem examination of the body is performed to determine the cause of death. Internal organs are studied by gross evaluation and correlated with histopathological fi ndings. Lung pathologies include a wide range of infectious, infl ammatory, neoplastic, and occupational diseases. Determining the cause of death helps in future patient management and also helps to adopt prophylactic measures to prevent pulmonary dysfunction. This study evaluates the histopathological spectrum of pulmonary lesions in autopsies, which were the direct cause of death or incidental fi ndings. This was a retrospective study conducted on lung autopsies, in the department of pathology, for a period of 4 years. After gross examination, formalin fi xed paraffi n-embedded lung sections were stained, histopathological evaluation was performed, and fi ndings were recorded and tabulated. Statistical analysis based on frequency was done. This study includes a total of 240 cases. The most common age group was between 41 to 50 years, followed by 31 to 40 years. Also, a male predominance of 74.58% was noted in the study. On histopathological evaluation, 7.5% of cases were autolyzed, and 4.16% had normal histomorphology. The most common fi nding was mild pulmonary congestion, followed by pulmonary edema. These fi ndings can occur secondary to a terminal event. Hence the most common fi nding that can cause mortality is acute pneumonia. Other common fi ndings were emphysema, diff use alveolar damage, intra-pulmonary hemorrhage, and pulmonary vein thrombosis. Infectious pathologies are the main pulmonary lesions that lead to death. Early diagnosis and treatment can reduce these preventable causes of mortality. Acute pneumonia is the most common pathology that accounts for mortality. Pulmonary tuberculosis also contributes a fair number to mortality. Early diagnosis and treatment can reduce these preventable causes of mortality. Public awareness about these diseases can reduce morbidity and mortality to a greater extent.


References

  • 1.   Goswami PR, Goswami AP, Khandkar AS. Autopsy study of the spectrum of lung lesions in Tertiary care hospital. J Fam Med Prim Care. 2021;10(3):1251–3.
  • 2.   Singh S, Bhushan R, Agarwal K, Chhikara A, Anand A. Autopsy Finding in Lung and Liver: A Histopathological Study. Natl J Lab Med. 2019;8(1):7–11.
  • 3.   Khare P, Gupta R, Ahuja M, Khare N, Agarwal S, Bansal D. Prevalence of Lung Lesions at Autopsy: A Histopathological Study. J Clin Diagn Res. 2017;11(5):13–6.
  • 4.   Chauhan G, Agrawal M, Thakkar N, Parghi B. Spectrum of histopathological lesions in lung autopsy. J Res Med Dent Sci. 2015;3(2):109–12.
  • 5.   Patel CB, Patel K, Bhagat VM, Shah P. Pattern of histopathological lesions in lung autopsy. Int J Res Med Sci. 2017;6(1):279– 83.
  • 6.   Berezowska S, Schmid A, Losmanová T, Trippel M, Blank A, Banz Y, et al. Frequency and Significance of Pathologic Pulmonary Findings in Postmortem Examinations—A Single Center Experience before COVID-19. Diagnostics. 2021;11(5):894.
  • 7.   G. S, S. A, Chakravarthi D, S. R. Histopathological study of the lung in autopsy cases: a prospective study. Int J Res Med Sci. 2016;4(11):4816–9.
  • 8.   TM T, F R, S A, F K. Pattern of pulmonary morphological lesions seen in autopsy. Biomedica. 2013;29:64–8.
  • 9.   Shetty A, C V. A five-year study of lung lesions in medicolegal autopsies from a pathologist’s perspective. J Diagn Pathol Oncol. 2020;3(4):344–9.
  • 10.   Kour B, Singh K, Kaur A. Histopathological Spectrum of Lesions in Lung Autopsy- A One Year Retrospective Study. Int J Res Rev. 2019;6(8):168–71.
  • 11.   TS A, K S, T R, PS S. Patterns of Lung Lesions in Autopsy: A Histopathological Study. Indian J Forensic Med Pathol. 2020;13(1):9–13.
  • 12.   RS G, GM K, BR N. Histopathological Spectrum of Lung Lesions in Autopsy. IOSR J Dent Med Sci. 2019;18(6):16–20.
  • 13.   Amin N, Shah P, Patel R, Khant V, Prajapati S. Histopathological alterations in lung tissue received as autopsy specimens- a study of 410 cases. Int J Med Sci Public Health. 2017;6(2):1.
  • 14.   SK U, P S, GU K, Pruthvi D. Histomorphogical Pattern of Lung in Medicolegal Autopsies. Int J Sci Res. 2015;4(7):1937–9.
  • 15.   S S, SP P. Acute respiratory distress syndrome: an autopsy study. J Postgrad Med Educ Res. 2014;48(1):8–13.
  • 16.   VR S, T S, PM S. Prevalence of common disease in lungs and liver: A histopathological study. J Pharm Biomed Sci. 2011;12(9):1–5.
  • 17.   Akarte DS, Hinnawi SA, Kude RP. Gross and Histopathological Findings in Fatalities Caused by Pulmonary Disease: An Autopsy Study. Ann Int Med Dent Res. 2019;5(3):13–7.
  • 18.   Madani M, Jamieson S. Chronic thromboembolic pulmonary hypertension. Curr Treat Options Cardiovasc Med. 2000;2:141–8.
  • 19.   Terrabuio AA, Parra ER, Farhat C, Capelozzi VL. Autopsy-proven causes of death in lungs of patients immunocompromised by secondary interstitial pneumonia. Clin Sci. 2007;62(1):69–76.
  • 20.   Hiroko lizuka, Mori Y, Fukuda Y, Iwao N, Koike M, Noguchi M. Two autopsy cases of pulmonary leukemic infiltration mimicking severe pneumonia in patients with acute myeloid leukemia. Leuk Res. 2021;16:100–4.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest in this work.


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Cite this article

Athira KP, Kumar M, Chaitra BE. Histopathological spectrum of pulmonary lesions: an autopsy based study. Indian J Forensic Med Pathol. 2023;16(2):101-106.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator


Received Accepted Published
January 13, 2023 April 03, 2023 June 30, 2023

DOI: https://doi.org/10.21088/ijfmp.0974.3383.16223.2

Keywords

Autopsy; Lung diseases; Pulmonary edema; Pneumonia; Emphysema.EmphysemaPneumoniaAutopsyLung diseasesPulmonary edemaAutopsy; Lung diseases; Pulmonary edema; Pneumonia; Emphysema.

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Received January 13, 2023
Accepted April 03, 2023
Published June 30, 2023

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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator


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