Home > Journals > Indian Journal of Pathology: Research and Practice

Indian Journal of Pathology: Research and Practice

Submit your article Read this Journals View all journals
Full Text (PDF)
Original Article

Hematological Profile in Acute Organophosphorous Compound Poisoning

Nirmala Mysore Jayakumar, Associate Professor, Department of Pathology, P.E.S. Institute of Medical Sciences and Research, Kuppam, Andhra Pradesh 517425, India. , Thinakaran Vijithaa , Nirmala Mysore Jayakumarb , Udaya Kumar Manikyamc , Rudrappa Prashanthd

Author Information

Licence:



Indian Journal of Pathology: Research and Practice 7(2):p 198-201, February 2018. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7218.11

How Cite This Article:

Timeline

Received : N/A         Accepted : N/A          Published : N/A

Abstract

Context: Organophosphorus (OP) compounds are the most common suicidal poisons in the developing countries. A recent study from south India reported mortality rate of 4% in OP poisoning cases.These compounds exert their toxicity by allowing acetylcholine to overact at its receptors in the central and peripheral nervous system. Aims: The aim was to study the variations in the hematological parameters in patients of OP compound poisoning and clinically correlate these findings with the severity of poisoning and assess the effect of treatment on them. Methods and Material: Patients with definite history of OP compound poisoning and decreased serum levels of pseudocholinesterase (PCE) enzyme were included in the study. The serum pseudocholinesterase levels were estimated at admission. Another EDTA blood sample was subjected to complete blood picture analysis. The same methodology was repeated after treatment. OP poisoning patients were classified into latent, mild, moderate and severe based on serum pseudocholinesterase levels. Concurrently the changes in hematological parameters were correlated with the severity of poisoning before and after treatment. Statistical Analysis Used: Statistical analysis of the percentages, mean, range and chisquare test for associations and Wilcoxon signed-rank test to assess the association were done, with p-value of <0.05 taken as statistical significance at 95% confidence interval Results: The present study showed significant decrease (p<0.001) in serum cholinesterase levels in moderate to severe poisoning. Out of 164 cases, 80 of them showed neutrophilia at admission and reached to values of normal reference range in 81.2% of the cases post-treatment while neutophilia persisted in 18.8% despite treatment which is statistically significant. Conclusions: This study concludes that in resource poor settings where estimation of plasma ChE levels cannot be determined then hematological parameters like total and differential leucocyte counts can predict response to treatment and recovery from OP poisoning.

Keywords: Organophosphorus Compounds; Poisoning; Serum Pseudocholinesterase; Neutrophilia. 

References

No records found.


About this article

Cite this article

Licence:



Received Accepted Published
N/A N/A N/A
DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.7218.11

Keywords


Article Level Metrics

Last Updated

Sunday 12 July 2026, 13:45:46 (IST)

2018

Accesses

3
434
00

Citations


NA
NA
NA

Download citation


Article Keywords

Keyword Highlighting

Highlight selected keywords in the article text.


Timeline

Received N/A
Accepted N/A
Published N/A

licence




Access this article

Reprint Order Form
Buy this Article
Institutional Subscriptions

Share