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Pediatric Education and Research 4(2):p 63-65, May-Aug 2016. | DOI: DOI: https://dx.doi.org/10.21088/per.2321.1644.4216.4
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Antimicrobial Sensitivity Pattern of Salmonella Typhi in Eastern Uttar Pradesh
Rajniti Prasad* , Rajniti Prasad* , P.C. Jha** , O.P. Mishra*
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Pediatric Education and Research 4(2):p 63-65, May-Aug 2016. | DOI: DOI: https://dx.doi.org/10.21088/per.2321.1644.4216.4
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Abstract
Background: Enteric fever is common waterborne disease in India and poses a therapeutic challenge in children due to emergence of drug resistant organism. Objective: the present study was undertaken to review the changes in antibiotic sensitivity and resistance pattern of almonella typhi in eastern Uttar Pradesh. Methods: The study consisted of 79 clinically and serologically confirmed cases of enteric fever aged 215 years from may 2009 to January 2015 and subjected to blood culture and sensitivity. We had not done phage typing of isolated organism. Results: almonella typhi was sensitive to ciprofloxacillin, cefotaxime, ceftriaxone and cefixime in 75%, 72%,71% and 72% respectively and resistant to both ciprofloxacillin and ceftriaxone in 38%. There is declining trend in resistant pattern to amoxicillin, chloramphenicol and cotrimoxazole as observed and reported from same institute in 1996. Conclusion: The drug resistant enteric fever still remains a therapeutic challenge and combination therapy with ceftriaxone and other antimicrobials may be another option.
Keywords: Enteric fever; Salmonella typhi; Sensitivity.
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DOI: DOI: https://dx.doi.org/10.21088/per.2321.1644.4216.4
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