Abstract

Background: Extramedullary Involvement (EMI) in acute leukemia refers to the infiltration of leukemic cells into organs or tissues outside of the blood or bone marrow compartments. This phenomenon manifests in various locations such as the skin, bones, and lymph nodes. Case report: We present an uncommon occurrence involving a 46-year-old male, wherein extensive myeloid infiltrates were identified during autopsy examination. Literature review: EMI is believed to manifest in approximately 3-8% of adults diagnosed with Acute Myeloid Leukemia (AML).1 Clinical relevance: It highlights the diagnostic complexity of AML and emphasizes the need for meticulous gross and microscopic examination during autopsy with clinicopathological correlation and utilization of special tests like immunohistochemistry in diagnosing such rare entities.

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