Kajol Bhati Associate Professor, Department of Forensic Science, Galgotias University, Greater Noida, Uttar Pradesh,, India
Christo S. Cherian Student, Department of Forensic Science, Galgotias University, Greater Noida, Uttar Pradesh, India
Mansi Mishra Student, Department of Forensic Science, Galgotias University, Greater Noida, Uttar Pradesh,, India
Address for correspondence: Kajol Bhati, Associate Professor, Department of Forensic Science, Galgotias University, Greater Noida, Uttar Pradesh,, India E-mail: bhati.kajol18@gmail.com
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Cherian CS, Mishra M, Bhati K. Y-Chromosome Short Tandem Repeats: A Review. Indian J Forensic Med Pathol. 2025;18(2 Suppl):251-259.
Timeline
Received : June 28, 2024
Accepted : June 28, 2025
Published : June 30, 2025
Abstract
Since the early 1990s, the effective development of forensic Y-chromosome examination has led to its widespread use as a standard procedure in labs handling cases involving crime worldwide. The Y-chromosome is a powerful tool in forensic genetics since it can spot the masculine DNA through the most likely to vary genomic sequence the so called STRs. These sequences could be considered to be an irreplaceable asset to the generally worldwide used array of non-sex chromosomal loci used in the study of genetics with respect to forensics. The focus
on the masculine part of the chromosome makes it specifically of huge regard in cases of the lumping up of feminine and masculine cell, such as in scenarios of defilement in sexual aspect. However, single set stature of chromosome and the father to son passover of the masculine genetic material can make the detection and study of the short tandem repeats spotted on the male chromosomal gene difficult when males have the exact same Y-chromosomal make up for n number of generations. This may complicate the very understanding of the fact that whether a DNA profile belongs to a suspect or a paternal relative. On the other hand, Y-chromosome research can be used to study the very formation of a DNA profile in a given population which further enables us to study population genetics. As it is also evident that the people falling in the same patrilineal line generally do
stay in the same place they were born indicating that there could not be much of a change in their culture and habitat, study of the masculine genetic material thus could be of great significance in understanding the habitat and culture of an entire population. The study of forensic Y-chromosome analysis includes the disciplines of application of Y-genome haplotyping, the evaluation of outcomes, making a track of data of new projects and efforts. This field has played a critical role in criminal investigations, and its continued development promises to bring even greater benefits to forensic genetics.
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Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest.
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Cite this article
Cherian CS, Mishra M, Bhati K. Y-Chromosome Short Tandem Repeats: A Review. Indian J Forensic Med Pathol. 2025;18(2 Suppl):251-259.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
The PowerPlex Y23 delivers the corresponding positions of 23 Y-STR loci. The strong written content indicates the six novel loci. The pseudo autosomal domains PAR1 and PAR2 on the ends of Y-chromosome reconnect with the X chromosome. The area that is covered round AMEL Y may sometimes be removed, leaving gaps in usually complete Y-STR profiles for loci like DYS458. The gap between DYS391 and AMEL Y prevents deletions from occurring.
Description: No description available.
Compositions of Human Y chromosome and information of 62 Y-STR markers24