This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Indian Journal of Forensic Medicine and Pathology
14(2 (Special Issue)):p 301-308, April-June 2021. | DOI: 10.21088/ijfmp.0974.3383.14221.41
How Cite This Article:
Yadav S. Toxicological aspects of Ayurvedic medicines: a review. Indian J Forensic Med Pathol. 2021;14(2 Special):301-8.
Timeline
Received : April 02, 2021
Accepted : April 20, 2021
Published : June 30, 2021
Abstract
Ayurvedic medicine is considered to be one of the oldest medical systems in the
world, and it is based on the ancient Indian medical philosophy i.e. depend on a
“natural” and holistic mental and physical health approach and it remains one of the
mainstream health care systems in India. Ayurvedic medicines are very popular in
India and other Asian & Western countries as an alternative to chemical medicines
because of their no / very few side effects on the human body. Ayurvedic medicines
are known for the treatment of chronic diseases such as cancer, diabetes, arthritis, and
asthma. This paper describes the possible causes for the various types of toxicity occurring/reported due to the intake of different types of Ayurvedic bhasma (nanoparticles)
and herbal medicines, among them heavy metal toxicity (Lead, Mercury, Arsenic) is
commonly seen. Many medicinal plant preparation could interfere with the proper
functioning of certain medicines like Phenobarbital, Alprazolam, etc. The contamination of Herbal Medicines from heavy metals or microbial toxins can lead to nephrotoxicity, neurotoxicity, Hepatotoxicity, and severe damage to other body organs. Due to nonavailability of proper data on short, medium, and long term usage of Ayurvedic
Bhasmas, heavy metal toxicity has been reported. Ayurvedic Bhasmas are safe though
a lack of standard protocol or method of preparation.
References
1. World Health Organization. Benchmarks for training in Ayurveda: benchmarks for training in traditional complementary and alternative medicine. Geneva: World Health Organization; 2010. p. 48.
2. Ranawat A. A brief review about Ayurveda. Int J Complement Alt Med. 2017;5(6):00170.
3. Kumar A, Nair AGC, Reddy AVR, Garg AN. Bhasmas: unique Ayurvedic metallic–herbal preparations, chemical characterization. Biol Trace Elem Res. 2006;109(3):231-54.
4. Ministry of AYUSH. Government of India [Internet]. New Delhi: Ministry of AYUSH; [cited 2020 Jul 21]. Available from: https://www.ayush.gov.in/
5. Dasgupta A. Review of abnormal laboratory test results and toxic effects due to use of herbal medicines. Am J Clin Pathol. 2003;120(1):127-37.
6. Saper RB, Phillips RS, Sehgal A, Khouri N, Davis RB, Paquin J, et al. Lead, mercury, and arsenic in US- and Indian-manufactured Ayurvedic medicines sold via the Internet. JAMA. 2008;300(8):915-23.
7. NYC Health Department. Some Baidyanath products contain lead: NYC Health Department [Internet]. The Economic Times; 2015 [cited 2026 Jan 21]. Available from: https://economictimes.indiatimes.com/industry/healthcare/biotech/healthcare/some-baidyanath-products-contain-lead-nyc-health-department/articleshow/48214967.cms
8. Houston Health Department. Lead in Indian remedies [Internet]. Houston: Houston Health Department; [cited 2026 Jan 21]. Available from: https://www.houstontx.gov/health/NewsReleases/Lead%20in%20Indian%20Remedies.pdf
9. Health Canada. Health Canada warns consumers not to use certain Ayurvedic medicinal products [Internet]. Ottawa: Health Canada; 2005 [cited 2026 Jan 21]. Available from: https://www.healthycanadians.gc.ca/recall-alert-rappel-avis/hc-sc/2005/13699a-eng.php
10. Philips CA, Paramaguru R, Augustine P. Ayurveda metallic-mineral ‘Bhasma’-associated severe liver injury. BMJ Case Rep. 2018;2018:bcr-2018-224696.
11. Soloneski S, Larramendy ML. Toxic effects as a result of herbal medicine. In: Larramendy ML, editor. Toxicology: new aspects to this scientific conundrum. London: IntechOpen; 2016.
12. Gow PJ, Connelly NJ, Hill RL, Crowley P, Angus PW. Fatal fulminant hepatic failure induced by a natural therapy containing kava. Med J Aust. 2003;178(9):442-3.
13. Jamieson DD, Duffield PH. Comparison of the central nervous system activity of the aqueous and lipid extract of kava (Piper methysticum). Arch Int Pharmacodyn Ther. 1990;306(1):66-80.
14. Abbott PJ. Comfrey: assessing the low‐dose health risk. Med J Aust. 1988;149(11-12):678-82.
15. Ridker PM, Ohkuma S, McDermott WV, Trey C, Huxtable RJ. Hepatic venocclusive disease associated with the consumption of pyrrolizidine-containing dietary supplements. Gastroenterology. 1985;88(4):1050-4.
16. Hirono I, Mori H, Haga M. Carcinogenic activity of Symphytum officinale. J Natl Cancer Inst. 1978;61(3):865-9.
17. Rosenblatt M, Mindel J. Spontaneous hyphema associated with ingestion of Ginkgo biloba extract. N Engl J Med. 1997;336(15):1108.
18. Gurley BJ, Gardner SF, White LM, Wang PL. Ephedrine pharmacokinetics after the ingestion of nutritional supplements containing Ephedra sinica (ma huang). Ther Drug Monit. 1998;20(4):439-45.
19. Haller CA, Benowitz NL. Adverse cardiovascular and central nervous system events associated with dietary supplements containing ephedra alkaloids. N Engl J Med. 2000;343(25):1833-8.
21. Wu TN, Yang KC, Wang CM, Lai JS, Ko KN, Chang PY. Lead poisoning caused by contaminated Cordyceps, a Chinese herbal medicine: two case reports. Sci Total Environ. 1996;182(1-3):193-5.
22. Haller CA, Dyer JE, Ko R, Olson KR. Making a diagnosis of herbal-related toxic hepatitis. West J Med. 2002;176(1):39-44.
23. Sandler B, Aronson P. Yohimbine-induced cutaneous drug eruption, progressive renal failure, and lupus-like syndrome. Urology. 1993;41(4):343-5.
24. Chou WC, Wu CC, Yang PC, Lee YT. Hypovolemic shock and mortality after ingestion of Tripterygium wilfordii Hook F.: a case report. Int J Cardiol. 1995;49(2):173-7.
25. Willey LB, Mady SP, Cobaugh DJ, Wax PM. Valerian overdose: a case report. Vet Hum Toxicol. 1995;37(4):364-5.
26. Markowitz JS. Effect of St John's wort on drug metabolism by induction of cytochrome P450 3A4 enzyme. JAMA. 2003;290(11):1500-4.
28. Shader RI, Greenblatt DJ. Phenelzine and the dream machine—ramblings and reflections. J Clin Psychopharmacol. 1985;5(2):65.
29. Patel NM, Derkits RM. Possible increase in liver enzymes secondary to atorvastatin and black cohosh administration. J Pharm Pract. 2007;20(4):341-6.
30. Yi S, Cho JY, Lim KS, Park KD, Jang IJ, Yu KS, et al. Effects of Angelicae tenuissima radix, Angelicae dahuricae radix and Scutellariae radix extracts on cytochrome P450 activities in healthy volunteers. Basic Clin Pharmacol Toxicol. 2009;105(4):249-56.
31. Dandekar UP, Chandra RS, Dalvi SS, Joshi MV, Gokhale PC, Sharma AV, et al. Analysis of a clinically important interaction between phenytoin and Shankhapushpi, an Ayurvedic preparation. J Ethnopharmacol. 1992;35(3):285-8.
32. Piscitelli SC, Burstein AH, Welden N, Gallicano KD, Falloon J. The effect of garlic supplements on the pharmacokinetics of saquinavir. Clin Infect Dis. 2002;34(2):234-8.
33. El-Shemy H. Aromatic and medicinal plants: back to nature. In: El-Shemy H, editor. Aromatic and medicinal plants: back to nature. London: IntechOpen; 2017.
34. Slifman NR, Obermeyer WR, Aloi BK, Musser SM, Correll WA Jr, Cichowicz SM, et al. Contamination of botanical dietary supplements by Digitalis lanata. N Engl J Med. 1998;339(12):806-11.
35. Pal SK. The Ayurvedic bhasma: the ancient science of nanomedicine. Recent Pat Nanomed. 2015;5(1):12-8.
36. Nagarajan S, Krishnaswamy S, Pemiah B, Rajan KS, Krishnan UM, Sethuraman S. Scientific insights in the preparation and characterisation of a lead-based Naga Bhasma. Indian J Pharm Sci. 2014;76(1):38-45.
37. Sarkar PK, Chaudhary AK. Ayurvedic bhasma: the most ancient application of nanomedicine. J Sci Ind Res. 2010;69(12):901-5.
38. Sushma D, Dinesh K. Metal bhasmas: a possible source of trace elements. Int J Ayurveda Pharm Res. 2016;4(8):72-4.
39. Liu J, Zhang F, Ravula R, Goparaju A, Bhasin VK, Jamwal R, et al. Chemical compositions of metals in Bhasmas and Tibetan Zuotai are a major determinant of their therapeutic effects and toxicity. Evid Based Complement Alternat Med. 2019;2019:1697804.
40. Saraswathy A, Ruckmani SR, Ariyanathan S. Chemical analysis of Vangha Bhasma. Int J Res Ayurveda Pharm. 2013;4(5):676-9.
41. Chandran S. Particle size estimation and elemental analysis of Yashada Bhasma. Int J Green Pharm. 2017;11(4):S212.
42. Chauhan A, Semwal DK, Mishra SP, Semwal RB. Ayurvedic research and methodology: present status and future strategies. Ayu. 2015;36(4):364-9.
43. Gadi R, Rattan S, Mohapatra S. Environmental studies. New Delhi: S.K. Kataria & Sons; 2008.
About this article
Cite this article
Yadav S. Toxicological aspects of Ayurvedic medicines: a review. Indian J Forensic Med Pathol. 2021;14(2 Special):301-8.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.