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Indian Journal of Pathology: Research and Practice

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Study of Utility of p63 Immunohistochemical Stain to Differentiate Urothelial Carcinomas of Urinary Bladder from Adenocarcinomas of Prostate

Dr. Bhavani A., Plot no135 & 136, Flat no: 301, Akruthi Sulochana towers, near badminton court, KTR colony roadno: 5, Nijampet, Hyderabad500090, India. , Bhavani Adepu* , Prasuna Chilveri** , Anunayi***

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Indian Journal of Pathology: Research and Practice 6(3(part-1)):p 535-540, Jul-Sep 2017. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6317.5

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Abstract

Introduction: Cancer of the bladder and of prostate are commonmalignancies all over the world. In some cases it is difficult to point to the exact primary due to the anatomical location and morphology of the tumors from these two sites. Various immunohistochemical markers can be used to identify the primary site and p63 is one such marker. Aim of the study: To study the expression of p63 in urothelial carcinoma and prostatic adenocarcinoma so as to differentiate between the two carcinomas. Materials and Methods: In this study, formalin fixed paraffin blocks from 60 cases of urothelial carcinomas of urinary bladder and 20 cases of prostatic adenocarcinomas were examined on light microscopy and tissue sections from all 80 cases were studied for immunohistochemical staining with p63 marker. Observations and Results: The mean age of patients of urothelial carcinoma and of prostate carcinoma was 54.1 and 64.5 years respectively. There were 28 cases (46.6%) of low grade and 32 cases (53.3%) of high grade urothelial carcinomas. The Gleason score for prostatic carcinoma was 56 for 8 patients, 78 for 9 patients and 910 for 3 patients.In 60 urothelial carcinomas 90% of cases showed p63 positivity. All the 20 cases of prostatic adenocarcinomas were negative for p63. Conclusion: p63 is a reliable marker of urothelial differentiation and it can be used in morphologically difficult cases when the differential diagnosis is between poorly differentiated adenocarcinoma of prostate and high grade urothelial carcinoma of urinary bladder.

Keywords: Urothelial Carcinoma of Bladder; Prostatic Carcinoma; p63 Staining.

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6317.5

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