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Study of Platelet Parameters in Non Dialysis Dependent CKD Patients

Hawaldar Ranjana* , Hawaldar Ranjana* , Sodani Sadhna**

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Indian Journal of Pathology: Research and Practice 4(2):p 59-63, July - September 2015. | DOI: DOI : https://dx.doi.org/10.21088/ijprp.2278.148X.4215.4

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Abstract

 Introduction: Automated blood cell counters have made it easy to quantify RBC, WBC and platelet parameters. RBC & WBC parameters have been widely studied with the introduction of automated hematology analysers but platelet parameters have started receiving attention in the last few years only. Most important platelet parameters are plateletcrit (PCT), mean platelet volume (MPV) and platelet distribution width (PDW). Platelets dysfunctions are common in CKD. The present study was conducted with the primary aim of evaluating the platelet parameters in nondialysis dependent CKD patients coming to our diagnostic centre. Materials and Methods: The present study was carried out in 100 CKD patients coming to our diagnostic centre from January 2015 to May 2015.All patients with a creatinine value of more than 1.5 mg/dl were included in the study. 100 age matched controls were used for the comparison study. Statistical analysis was performed by partial correlation test. Mean and SD of each platelet parameter was calculated for both patients and controls and the results were compared using students t– test. Results: In the CKD patients group, the mean platelet count was 264.4±91.3x 103/μL,MPV was 7.6±0.9fl, PCT was 0.197±0.066%, PDW was 16.5 ±0.9, creatinine was 3.968±2.676 mg/dl.For the control group, the mean platelet count was 299.6±99.8 x103/μL, MPV was 7.8±1.0 fl, PCT was 0.230±0.067 %,PDW was 16.5 ±1.0, creatinine was 0.908 ± 0.246 mg/dl. T test was done for the control and CKD patients group which showed difference in values of platelet counts, PCT and creatinine values in both groups while MPV and PDW did not show much difference. Conclusion: CKD patients do not show much variation in platelet parameters as compared to age matched controls. However, a much larger study is needed to confirm the findings. MPV, PCT and PDW are simple platelet indices reported by all modern cell counters and need to be studied extensively in a larger study for a definite conclusion to be made.

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DOI: DOI : https://dx.doi.org/10.21088/ijprp.2278.148X.4215.4

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