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Emergence of Anti-Citrullinated Protein in the Early Diagnosis of Rheumatoid Arthritis: A Study of more than 1000 Cases in a Standlone Laboratory

Sarmah S.** , Bhuyan M. P.* , Sarmah S.**

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Indian Journal of Pathology: Research and Practice 4(2):p 55-58, July - September 2015. | DOI: DOI : https://dx.doi.org/10.21088/ijprp.2278.148X.4215.3

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Abstract

 Introduction: Rheumatoid arthritis (RA) is one of the most common systemic autoimmune diseases. The aetiology of the disease, which affects up to 12 % of the world population, is unknown. This poor prognosis has led to an emphasis on early diagnosis and aggressive treatment. The routinely used diagnostic aid prescribed for Rheumatoid Arthritis is the serological test for the determination of rheumatoid factors (RF) in the serum. Methods and Materials: The antiCCP antibody kit used is based on an ELISA method. All the antiCCP positive cases were tested for Rheumatoid factor (RF) with turbidmetric immunoassay method. A total of 1024 cases were tested for Anti citrullinated peptide (Anti CCP). Of these 216 cases has been reported positive. Result: Positive AntiCCP was found to be most prevalent in the age group: 41 – 50 years. In females the positive percent is 77. 3 %. Of the positive Anti –CCP cases only 68 were positive for Rheumatoid Factor (direct test with undiluted serum). Discussion & Conclusion: This study emphasised the value of antiCCP antibodies as an early diagnostic marker of RA. The results are consistent with other relevant reviews. AntiCCP antibodies precede the onset of RA and their presence is indicative of the future development of RA, making early therapeutic intervention possible.  

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DOI: DOI : https://dx.doi.org/10.21088/ijprp.2278.148X.4215.3

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