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Study of Hepatic Dysfunction of Dengue Fever in Children

unil Natha Mhaske , Santoshi Kankante1 , Sunil Natha Mhaske2 , Sharada Aher3

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Pediatric Education and Research 7(1):p 3-6, January-March 2019. | DOI: DOI: https://dx.doi.org/10.21088/per.2321.1644.7119.1

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Abstract

 Background: Dengue is a major international problem that is prevalent in tropical and sub-tropical countries. It is estimated that worldwide nearly 2.5 billion people continue to live at risk of contracting the infection while 50 million cases and 24,000 deaths tend to occur in 100 endemic countries. Hepatic dysfunction is common in dengue fever and the degree of liver dysfunction in children varies from mild injury with to severe injury. Methods: Prospective and descriptive study was conducted on all the laboratory confirmed cases of dengue fever in children admitted at our institute in Department of Paediatrics over a period of 1 year clinically and biochemically. Results: This study reveals, the prevalence of hepatic dysfunction in 30.7% (160/500) of the cases. Among the gender and age, majority of the hepatic dysfunction were seen in males 53.7% (86/160) and in the age group of 10- 18 years 45% (72/160). Based on the severity, majority of hepatic dysfunction with severe dengue cases were 60% (96/160). Among clinical findings, most common symptom was jaundice 23.7% (38/160) and commonest sign was hepatomegaly 39.3% (63/160). The commonest liver function test altered was AST level in 46.2% (74/160) of the cases. Commonest abdominal USG finding was gall bladder edema in 90.6% (145/160) of the cases. The mortality was nil in this study. Conclusions: This study concludes prevalence of hepatic dysfunction was seen 30.7%, most of them seen in severe dengue 60% of the cases suggesting any febrile child with hepatic dysfunction, dengue infection should be suspected.

Keywords: Dengue Fever; Jaundice; Hepatic Dysfunction.

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DOI: DOI: https://dx.doi.org/10.21088/per.2321.1644.7119.1

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