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Study of CYP17 Gene Polymorphism in Fetal Growth Restriction with Reference to Organochlorine Pesticide Levels

Siddharth Chand , Siddharth Chand , Md. Mustafa , B.D. Banerjee , Kiran Guleria

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New Indian Journal of Surgery 3(3):p 177-177, July - September 2012. | DOI:

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Abstract

 The cytochrome P-450c17alpha enzyme encoded by the P-450c17alpha (CYP17) gene functions in the key steps of the estrogen synthesis pathway. The genetic variation in the maternal CYP17 gene leads to differences in estrogen level which affects fetal growth and causes fetal growth restriction (FGR). Organochlorine pesticides (OCPs) are endocrine disruptors which alter the normal estrogen-progesterone balance and are reported to be associated with adverse reproductive outcomes.

 

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