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Journal of Pharmaceutical and Medicinal Chemistry 10(2):p 57-61, July - Dec 2024. | DOI: https://doi.org/10.21088/jpmc.2395.6615.10224.3
Original Article
Spectrophotometric Determination and Validation of Clotrimazole in Pharmaceutical Formulations
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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Journal of Pharmaceutical and Medicinal Chemistry 10(2):p 57-61, July - Dec 2024. | DOI: https://doi.org/10.21088/jpmc.2395.6615.10224.3
How Cite This Article:
Archana S., G. Bhavani, Spectrophotometric Determination and Validation of Clotrimazole in Pharmaceutical Formulations. J Pharmaceut Med Chem. 2024;10(2): 57-61.Timeline
Received : October 10, 2024
Accepted : November 28, 2024
Published : December 25, 2024
Abstract
Aim: A simple, sensitive, and cost-effective spectrophotometric method has been developed and validated for the determination of clotrimazole in pharmaceutical formulations. Settings and Method: The method is based on the measurement of absorbance at a specific wavelength (250 nm) in a methanolic solution. The linearity, precision, accuracy, limit of detection (LOD), limit of quantitation (LOQ), and robustness were investigated according to ICH guidelines. Results: The proposed method showed excellent linearity in the range of 1-25 µg/mL with a correlation coefficient (r) of 0.9998. The results indicated that the method is suitable for routine quality control analysis of clotrimazole in bulk and tablet formulations. Conclusion: The method is validated according to ICH guidelines and all the parameters are under the limits and used for routine analysis labs.
References
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- 6. Sharma, S., & Kumar, M. (2016). A validated HPLC method for the estimation of clotrimazole in pharmaceutical preparations. Journal of Liquid Chromatography & Related Technologies, 39(5), 241-247.
- 7. Shah, N. P., & Patel, N. M. (2015). Simultaneous estimation of clotrimazole and betamethasone dipropionate in pharmaceutical formulations by RP-HPLC. International Journal of PharmTech Research, 8(2), 235-240.
- 8. Batra, V., & Saini, S. (2016). Development and validation of an RP-HPLC method for clotrimazole in pharmaceutical formulations and biological fluids. Indian Journal of Pharmaceutical Sciences, 78(6), 828-835.
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Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
About this article
Cite this article
Archana S., G. Bhavani, Spectrophotometric Determination and Validation of Clotrimazole in Pharmaceutical Formulations. J Pharmaceut Med Chem. 2024;10(2): 57-61.
Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
| Received | Accepted | Published |
|---|---|---|
| October 10, 2024 | November 28, 2024 | December 25, 2024 |
DOI: https://doi.org/10.21088/jpmc.2395.6615.10224.3
Keywords
SpectrophotometryICH guidelinesValidation parametersSearch for Similar Articles
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Timeline
| Received | October 10, 2024 |
| Accepted | November 28, 2024 |
| Published | December 25, 2024 |
licence
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
