Abstract

The present study focuses on the formulation and evaluation of curcumin lozenges designed for the treatment of throat infections. Curcumin, a bioactive compound with antifungal, anti-inflammatory, and antioxidant properties, is known for its low bioavailability and dissolution rate. The aim was to develop a lozenge dosage form that enhances curcumin’s bioavailability and dissolution, making it suitable for pediatric, geriatric, and dysphagic patients. Lozenges were prepared using different polymers, namely HPMC K100, PEG 4000, and PEG 6000, at varying concentrations. The formulations were evaluated for various parameters including pH, drug content, drug release, and sterility. The FT-IR studies confirmed the compatibility of curcumin with the excipients. The results showed that all formulations had acceptable drug content and passed the sterility test. Among the three formulations, the one containing 2% HPMC K100M polymer (F3) demonstrated the best release characteristics, with 95.75% of the drug released within 45 minutes. Drug release kinetics followed the first-order model, suggesting a conventional release pattern. The Higuchi model further supported that the drug release followed a dissolution mechanism, consistent with the gel-based matrix structure of the polymers. Thus, the formulation containing HPMC K100M was optimized for curcumin lozenges, providing controlled drug release for effective throat infection treatment.

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