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Indian Journal of Anatomy 7(2):p 215-217, Mar-Apr 2018. | DOI: http://dx.doi.org/10.21088/ija.2320.0022.7218.19
Case Report
Schizencephaly: A Neuronal Progression Disorder
Junagade Bhavana S., Assistant Professor, Department of Anatomy, MGM Medical College, Kamothe, Navi Mumbai, Maharashtra, India. , Junagade Bhavana S.1 , Sabnis Anjali S.2
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Indian Journal of Anatomy 7(2):p 215-217, Mar-Apr 2018. | DOI: http://dx.doi.org/10.21088/ija.2320.0022.7218.19
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Abstract
Schizencephaly is a congenital cleft in cerebral mantle extending from pial surface to the lateral ventricle. It is lined by heterotopic grey matter. It is rare, with a prevalence of 1.48/1,00,000 births. In this case study, adult female brain specimen showed unilateral open lipped cleft - schizencephaly, in the left hemispheric perisylvian region communicating with the left lateral ventricular cavity. Cleft was lined by heterotopic grey matter. Schizencephaly is considered as the neuronal progression or migration disorder. It is also thought to be a brain segmentation disorder. This disruptive birth defect may have ischaemic - vascular injury at its root or it could be a presence of infection like Cytomegalo virus. Mutations in Homeobox gene EMX2 have been also implicated in this congenital anomaly. Our study indirectly confirms that unilateral cases of Schizencephaly may lead long life remaining undiagnosed till death.
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DOI: http://dx.doi.org/10.21088/ija.2320.0022.7218.19
Keywords
Unilateral Cerebral Cleft; Perisylvian; Open Lipped Cleft; Heterotopia.ÂSearch for Similar Articles
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