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Role of Platelet Indices for Predicting Vascular Complications in Type II Diabetics

Bhavana Grandhi, Associate Professor, Department of Pathology, Narayana Medical College, Nellore, Andhra Pradesh 524002, India. , Bhavana Grandhi1 , Grandhi V.R. Murthhi2 ,

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Indian Journal of Pathology: Research and Practice 7(11):p 1141-1144, November 2018. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.71118.6

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Abstract

Background: Diabetes mellitus is one of the most common diseases with hyperglycemia as the main etiological factor. Elevated blood sugars in the body are a predisposing factor for thrombosis. Vascular complications are a cause of the morbidity in diabetics. Mean Platelet Volume and Platelet Distribution Width are the platelet indices which are elevated in a thrombogenic state. Thus we have evaluated the role of these two parameters in type II diabetics. ims: • To calculate the Mean platelet volume and Platelet distribution width in both controls and cases • Correlate these indices with HbA1c, duration of diabetes and the presence of vascular complications in diabetics. Settings and Design study: Prospective. Methods and Material: A one year prospective study was done. 150 subjects were included divided into cases and controls. Cases were again divided into those with vascular complications (23) and those without vascular complications (52). Platelet indices were studied with special emphasis on Mean platelet volume and Platelet distribution width among both cases and controls. These were compared with glycosylated hemoglobin, duration of diabetes and presence of vascular complications. Statistical analysis used: SPSS. Results: Mean platelet volume and Platelet distribution width were elevated in diabetics when compared to non-diabetics and the increase was more relavant in those with complications. Statistical significance was seen with Mean platelet volume but not with Platelet distribution width. Conclusion: Our study thus highlights the differences in platelet indices among diabetics and non diabetics with emphasis on those with vascular complications. 

 

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.71118.6

Keywords

Mean Platelet Volume; Platelet Distribution Width; Diabetes; Complications. 

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