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Role of low hemoglobin level in predicting response to neoadjuvant chemotherapy in breast cancer and its correlation with p53, bcl-2 and VEGF – a prospective clinical study

Chintamani* , Chintamani* J.P. Singh** Rohan Khandelwal*** Megha Tandon**** Usha Agarwal***** Sunita Saxena******

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New Indian Journal of Surgery 1(1):p 13-21, Oct-Dec 2010. | DOI:

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Abstract

Neo-adjuvant chemotherapy (NACT) is an integral part of multi-modality approach in the management of locally advanced breast cancer (LABC). It is required both for the local control (to ensure microscopically free margins during surgery) and distant or systemic control [1-6]. Development of resistance to chemotherapeutic agents is a major and evolving problem. Various markers like P-Glycoprotein, tumor suppressor gene p53, apoptotic markers( Bcl-2, Bax) have been studied to predict the response to NACT[1].

Key words: Hemoglobin, breast cancer, neoadjuvant, Chemotherapy.

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