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Role of HER-2/Neu Expression in Premalignant and Malignant Lesions of Uterine Cervix

Rajesh Kumar Rai, Professor, Department of Pathology, B.R.D. Medical College, Gorakhpur, Uttar Pradesh 273013, India. , Shaila Kumari Mitra1 , Rajesh Kumar Rai2 , Kiriti Kanaujiya3 , Manjari Rao4

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Indian Journal of Pathology: Research and Practice 7(11):p 1171-1175, November 2018. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.71118.11

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Abstract

Background: HER-2/neu is a gene localized on chromosome 17q21 which encodes a growth factor receptor like molecule with tyrosine kinase activity and is known to encode a transmembrane glycoprotein. Aim: To study the expression of HER2/neu in benign and malignant lesions of cervix. Material and Methods: The present study was conducted on 100 cases of resected cervical tissue specimen suspected to have neoplastic lesions and hysterectomy specimen already diagnosed as carcinoma on cytology for a period of 12 months (September 2018 to August 2019). Results: Majority of benign cases were negative for HER-2/neu except few cases and positivity was higher in malignant than premalignant. Positivity was also higher in adenocarcinoma as compared to squamous cell carcinoma. Conclusion: HER-2/neu serves as a biological marker to identify high risk subgroups and can be useful as target for new treatment modalities.

 

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.71118.11

Keywords

Her-2 /neu; Epithelial Cells; Cervical Cancer.   

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