Pratima Manohar Pattar Tutor, Department of Pathology, ESIC Medical College, Kalaburagi, Gulburga, Karnataka 585106, India., India
Sainath K Andola Former Dean & Director, Professor, India
Umesh SR null Professor & HOD, Department of Forensic Medicine, GIMS, Kalaburagi, Gulburga, Karnataka 585105, India, India
Anuradha G Patil Professor & HOD, Department of Pathology, M.R Medical College, Kalaburagi, Gulbarga, Karnataka 585105, India., India
Address for correspondence: Pratima Manohar Pattar, Tutor, Department of Pathology, ESIC Medical College, Kalaburagi, Gulburga, Karnataka 585106, India., India E-mail: pratimapattar@gmail.com
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Andola SK, Pattar PM, Umesh SR, et al. (2020). Morphological Spectrum of Renal Lesions: An Autopsy Study. Indian Journal of Forensic Medicine and Pathology, 13(2):297–302.
Timeline
Received : March 13, 2020
Accepted : May 19, 2020
Published : June 30, 2020
Abstract
Context: Renal diseases are responsible for a great deal of morbidity and mortality. The
utopsy study throws immense light on pathogenesis of disease, reveals hazardous effects of
violence on various organs and lastly often reveals the cause of death.
Aims: To study the histomorphological spectrum of renal lesions in autopsies and an attempt
is made to establish the cause of death.
Design: Observational type of study
Materials and Methods: A prospective study was conducted from July 2016 to June 2018 in
the department of pathology. A total of 210 kidneys of adult medico legal autopsies performed
during the period were included in our study. The stained microscopic sections were examined
by two histopathologists independently.
Statistical Analysis: Descriptive analysis using IBM SPSS Statistics for Windows, Version 22.0.
Results: The age ranged from 4 to 80 years. Majority of the cases were in the age group of
21–30 years with a mean age of 33.40 years and the M:F ratio was 1.8:1. Out of 210 cases, 103
cases (49.1%) showed tubulo-interstitial and vascular lesions, 92 cases (43.81%) showed near
normal histology of kidney and 15 cases (7.1%) showed glomerular lesions.
Conclusions: The tubulo-interstitial lesions were more common than glomerular lesions in
medicolegal autopsies. The incidental finding in this study highlights the importance of gross
and microscopy examination of each organ in detail from each autopsy irrespective of the cause
of death.
References
1. Levey AS, Atkins R, Coresh J, et al. (2007). Chronic kidney disease as a global public health problem: approaches and initiatives: A position statement from Kidney Disease Improving Global Outcomes. Kidney International, 72:247–59.
2. Schiffrin EL, Lipman ML, Mann JF. (2007). Chronic kidney disease: effects on the cardiovascular system. Circulation, 116:85–97.
3. McClellan W. (2005). Epidemiology and Risk Factors for Chronic Kidney Disease. Medical Clinics of North America, 89:419–45.
4. Curtis B, Levin A, Parfrey P. (2005). Multiple Risk Factor Intervention in Chronic Kidney Disease: Management of Cardiac Disease in Chronic Kidney Disease Patients. Medical Clinics of North America, 89:511–23.
5. Covic A, Schiller A, Volovat C, et al. (2006). Epidemiology of renal disease in Romania: A 10 year review of two regional renal biopsy databases. Nephrology Dialysis Transplantation, 21:419–24.
6. Horvatic I, Tisljar M, Bulimbasic S, et al. (2013). Epidemiologic data of adult native biopsy proven renal diseases in Croatia. International Urology and Nephrology, 45:1577–87.
7. Solez K, Morel-Maroger L, Sraer JD. (1979). Morphology of “acute tubular necrosis” in man: analysis of 57 renal biopsies and a comparison with the glycerol model. Medicine (Baltimore), 58:362–76.
2. Schiffrin EL, Lipman ML, Mann JF. (2007). Chronic kidney disease: effects on the cardiovascular system. Circulation, 116:85–97.
3. McClellan W. (2005). Epidemiology and Risk Factors for Chronic Kidney Disease. Medical Clinics of North America, 89:419–45.
4. Curtis B, Levin A, Parfrey P. (2005). Multiple Risk Factor Intervention in Chronic Kidney Disease: Management of Cardiac Disease in Chronic Kidney Disease Patients. Medical Clinics of North America, 89:511–23.
5. Covic A, Schiller A, Volovat C, et al. (2006). Epidemiology of renal disease in Romania: A 10 year review of two regional renal biopsy databases. Nephrology Dialysis Transplantation, 21:419–24.
6. Horvatic I, Tisljar M, Bulimbasic S, et al. (2013). Epidemiologic data of adult native biopsy proven renal diseases in Croatia. International Urology and Nephrology, 45:1577–87.
7. Solez K, Morel-Maroger L, Sraer JD. (1979). Morphology of “acute tubular necrosis” in man: analysis of 57 renal biopsies and a comparison with the glycerol model. Medicine (Baltimore), 58:362–76.
9. • Berinde AM, et al. (2009). Assessment of chronic kidney disease based on necroptic microscopical examination in violent death cases. Romanian Journal of Legal Medicine, (3):205–212.
10. • Usta U, et al. (2014). Histopathological and immune alterations in autopsied kidneys. Saudi Medical Journal, 35(10):1331–38.
11. • Sandhu VK, Puri A, Singh N. (2017). Histomorphological Spectrum of Renal Lesion in An Autopsy Study. Annals of Pathology and Laboratory Medicine, 4(4).
12. • Ninomiya T, Kubo M, et al. (2007). Prehypertension Increases the Risk for Renal Arteriosclerosis in Autopsies: The Hisayama Study. Journal of the American Society of Nephrology, 18:2135–42.
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Andola SK, Pattar PM, Umesh SR, et al. (2020). Morphological Spectrum of Renal Lesions: An Autopsy Study. Indian Journal of Forensic Medicine and Pathology, 13(2):297–302.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.