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Indian Journal of Pathology: Research and Practice

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Lycopodiumclavatum and Conium Maculatum effect on Hearts of Mice Infected with Trypanosomacruzi

Denise Lessa Aleixo*** , Gislaine Janaina Falkowiski Temporini* , Camila Rafaela Cavaglier** , Melissa Ayumi Tanaka** , Silvana Marques de Araújo* , Denise Lessa Aleixo***

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Indian Journal of Pathology: Research and Practice 6(1):p 93-97, January - March 2017. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6117.15

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Abstract

 Chagas disease is a potentially fatal condition that presents high capacity to infect cardiac muscle cells and frequently evolves to dilated cardiomyopathy and congestive heart failure. The treatments available nowadays has low efficacy and several side effects, thus homeopathic medication is being studied as an alternative. Studies showed a decrease in the number of amastigotes in the heart of animals treated with Lycopodiumclavatum, a medication with anticholinesterasic, anti­inflammatory, antibacterial, antiviral and antifungal actions; and treated with Conium maculatum, a medication that acts in the nervous system by binding to nicotinic receptors. Therefore, the objective of this study was to describe the alterations verified in cardiac muscle cells of 12 Swiss male mice, 8 weeks old, infected with 1,400 trypomastigotes forms of T. cruzi (Y strain) and treated with Lycopodiumclavatum, 13cH –1:10 [26]dilution (GLy) and Conium maculatum 13cH –1:10 [26] dilution (GCo). The results showed that the mean relative heart weight of the animals in group GCO (0.76g) was significantly higher than the mean relative heart weight of the animals in group GCI ­ control group (0,52g) (p=0,01). The animals in group GLy presented a mean relative weight of 0,62g, showing no statistic difference compared to group GCI.

Keywords: Trypanosomacruzi; Chagas Disease; Heart.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6117.15

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