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Lipid Profile and Investment of Oxidants and Antioxidants in Hypertension and Ischemic Heart Disease of Tribal and Non-Tribal Patients

Aparna Misra* , Aparna Misra* , Farzana Mahdi** , Kanchan Singh*** , Pinky Purabia**** , S.L. Purabia***** , Anchal Trivedi****** , P.P. Singh*******

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Indian Journal of Pathology: Research and Practice 6(1):p 37-44, January - March 2017. | DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6117.6

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Abstract

 Introduction: Hypertension (HT) and Ischemic Heart Disease (IHD) are two pandemic cardiovascular health problems. The alarming feature of 1HD is that majority of burden is now shifting to developing and deprived economies. This includes India also. The present paper highlights the Lipid Profile, Oxidative Stress (OS) Nutrient Antioxidants and Endogenous Antioxidants Enzymes in Tribals, who represent deprived community, and non­tribals who represent developing community. Methods: This study included 353 subjects (Normal; tribals – 62, nontribals­52: HT­tribals­10 non­tribals­169: 1HD­tribals­4, non­trbal­41; HT+1HD­tribal­1 and non­tribal 14). All the subjects were investigated for lipid profile (Total Cholesterol, HDL­Cholesterol, LDLCholesterol, VLDL­Cholesterol, Triglyceride),Total Protein and Hb; antioxidant enzymes (SOD, GPx and Cat) and TBARS levels in blood and urine.Creatinine was also estimated in urine. Results: The total plasma cholesterol was almost touching the upper limit of normal in both tribals and non­tribals, was significantly higher iin IHD patients in both the communities. The LDL­ cholesterol (LDLC+VLDLC) was one of the important risk factors. OS (plasma TBARS) was significantly raised in IHD patients. Urine TBARS levels did not provide any conclusive trend. Vitamin A and beta­carotene levels were almost normal in both control and patient groups but vitamin C and E level and were low in both control and patients groups. SOD and GPx were low in patients group but catalase did not provide any regular trend. Conclusion: Cumulatively data suggest: I­ LDLCholesterol and triglyceride are risk factors, II ­Lop­sided redox status in patients.

Keywords: Lipid Profile; Oxidative Stress; Nutrient Antioxidants; Antioxidant Enzymes; Hypertension; Ischemic Heart Disease; Tribals; Non­Tribals.

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DOI: DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6117.6

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