Abstract

Leprosy, also known as Hansen's disease, is a chronic infectious disease caused by the bacterium Mycobacterium leprae. Clinical features depend on the immune status of the patient. Proper management of leprosy involves a comprehensive approach that includes diagnosis,
treatment, rehabilitation, and prevention of disabilities.
 

• 1.   ScienceDaily. DNA of Jesus-era shrouded man in Jerusalem reveals earliest case of leprosy [Internet]. 2009 [cited 2026 Feb 9].
• 2.   Fitness J, Tosh K, Hill AV. Genetics of susceptibility to leprosy. Genes Immun. 2002;3(8):441–53.
• 3.   Britton WJ, Lockwood DN. Leprosy. Lancet. 2004;363(9416):1209–19.
• 4.   Han XY, Sizer KC, Thompson EJ, Kabanja J, Li J, Hu P, et al. Comparative sequence analysis of Mycobacterium leprae and the new leprosy-causing Mycobacterium lepromatosis. J Bacteriol. 2009;191(19):6067–74.
• 5.   World Health Organization. Global leprosy situation, 2010. Wkly Epidemiol Rec. 2010;85(35):337–48.
• 6.   Gulia A, Fried I, Massone C. New insights in the pathogenesis and genetics of leprosy. F1000 Med Rep. 2010;2:30.
• 7.   Shimoji Y, Ng V, Matsumura K, Fischetti VA, Rambukkana A. A 21-kDa surface protein of Mycobacterium leprae binds peripheral nerve laminin-2 and mediates Schwann cell invasion. Proc Natl Acad Sci U S A. 1999;96(17):9857–62.
• 8.   Alter A, Grant A, Abel L, Alcaïs A, Schurr E. Leprosy as a genetic disease. Mamm Genome. 2011;22(1-2):19–31.
• 9.   Weddell G, Palmer E. The pathogenesis of leprosy: An experimental approach. Lepr Rev. 1963;34:57–61.
• 10.   Pedley JC. The nasal mucus in leprosy. Lepr Rev. 1973;44(1):33–5.
• 11.   Prabhakaran K, Harris EB, Randhawa B. Regulation by protein kinase of phagocytosis of Mycobacterium leprae by macrophages. J Med Microbiol. 2000;49(4):339–42.
• 12.   Ridley DS, Jopling WH. Classification of leprosy according to immunity: A five-group system. Int J Lepr Other Mycobact Dis. 1966;34(3):255–73.
• 13.   Ridley DS, Jopling WH. Classification of leprosy according to immunity: A five-group system. Int J Lepr Other Mycobact Dis. 1966;34(3):255–73.
• 14.   Ooi WW, Srinivasan J. Leprosy and the peripheral nervous system: Basic and clinical aspects. Muscle Nerve. 2004;30(4):393–409.
• 15.   Marahatta S, Bhattarai S, Paudel BH. Electrophysiological profiles of leprosy neuropathy. Lepr Rev. 2017;88(3):373–80.
• 16.   Thappa DM, Sharma VK, Kaur S, Suri S. Radiological changes in hands and feet in disabled leprosy patients: A clinicoradiological correlation. Indian J Lepr. 1992;64(1):58–66.
• 17.   Ankad BS, Hombal A, Rao S, Naidu VM. Radiological changes in the hands and feet of leprosy patients with deformities. J Clin Diagn Res. 2011;5(4):703–7.
• 18.   Maas M, Slim EJ, Heoksma AF, van der Kleij AJ, Akkerman EM, den Heeten GJ, et al. MR imaging of neuropathic feet in leprosy patients with suspected osteomyelitis. Int J Lepr Other Mycobact Dis. 2002;70(2):97–103.
• 19.   Wallis RS, Pai M, Menzies D, Doherty TM, Walzl G, Perkins MD, et al. Biomarkers and diagnostics for tuberculosis: Progress, needs, and translation into practice. Lancet. 2010;375(9729):1920–37.
• 20.   Notomi T, Okayama H, Masubuchi H, Yonekawa T, Watanabe K, Amino N, et al. Loop-mediated isothermal amplification of DNA. Nucleic Acids Res. 2000;28(12):E63.

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