Abstract

Introduction: Staphylococcus aureus is a commensal organism residing on human skin and mucosal surfaces as part of the normal flora. However, it is an opportunistic pathogen capable of causing infections when enters human body. The emergence of multidrug-resistant S. aureus, particularly methicillin-resistant strains (MRSA), has become a significant public health challenge. Aim: This study aimed to determine the prevalence and antimicrobial resistance patterns of S. aureus isolated from various body fluids. Methods: The bacterial samples were procured from Dr. Micro Lab between July 2024 and September 2024. S. aureus isolates were identified based on microscopic examination and biochemical tests. Antimicrobial susceptibility testing was performed using the Kirby-Bauer disk diffusion method on Mueller-Hinton agar. Results: Out of over 160 bacterial isolates, 70 were identified as S. aureus. Among these, 29 isolates (40%) were recovered from pus and wound infections. Methicillin-resistant S. aureus (MRSA) accounted for 33 (49%) of the S. aureus isolates. Resistance patterns showed that Linezolid exhibited no resistance, while Nitrofurantoin demonstrated the highest resistance rates. Conclusion: The study highlights a significant prevalence of S. aureus infections, particularly in females aged 21–30 years, with a higher frequency of isolates obtained from urine and pus infections. The findings show the growing resistance of S. aureus to commonly used antibiotics such as Penicillin and Erythromycin, raising concerns about treatment efficacy. However, Linezolid’s lack of resistance suggests it remains a reliable therapeutic option for managing MRSA infections.

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