Sunil V. Jagtap Professor, Department of Pathology and Physiology, Krishna Institute of Medical Sciences, Deemed University, Karad 415110, Maharashtra, India
Swati S Jagtap Associate Professor, Department of Pathology and Physiology, Krishna Institute of Medical Sciences, Deemed University, Karad 415110, Maharashtra, India
Pranjal Shah Assistant Lecturer, Department of Pathology and Physiology, Krishna Institute of Medical Sciences, Deemed University, Karad 415110, Maharashtra, India
Neha Desai Assistant Lecturer, Department of Pathology and Physiology, Krishna Institute of Medical Sciences, Deemed University, Karad 415110, Maharashtra, India
Rushit Shah Assistant Lecturer, Department of Pathology and Physiology, Krishna Institute of Medical Sciences, Deemed University, Karad 415110, Maharashtra, India
Dhwani Mawani Assistant Lecturer, Department of Pathology and Physiology, Krishna Institute of Medical Sciences, Deemed University, Karad 415110, Maharashtra, India
Address for correspondence: Sunil V. Jagtap, Professor, Department of Pathology and Physiology, Krishna Institute of Medical Sciences, Deemed University, Karad 415110, Maharashtra, India E-mail: drsvjagtap@gmail.com
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Sunil V. Jagtap, Swati S Jagtap, Pranjal Shah, et al./ Leiomyoma with Bizarre Nuclei: An Uncommon Variant of Uterine Smooth
Muscle Neoplasm/Indian Journal of Pathology: Research and Practice 2023;12(3) 105–108.
Timeline
Received : March 23, 2023
Accepted : June 15, 2023
Published : September 30, 2023
Abstract
Leiomyoma with bizarre nuclei (LBN) is an uncommon variant of uterine smooth muscle neoplasm. A 52 year female presented with complained of intermittent pelvic pain, abnormal uterine bleeding, and abdominal discomfort of 6 month duration. On ultrasonic evaluation showed well defined uterine masses suggestive of leiomyomas. The systemic examinations were normal. On histopathologycal finding reported as uterine leiomyoma with bizarre nuclei. Patient responded well to treatment. On follow up there was no evidence of recurrence. We are presenting this uncommon case of leiomyoma with bizarre nuclei for its clinical, radiological and histopathological findings. On histopathological findings this tumor should be properly differentiated form various uterine spindle cell tumors with nuclear atypia for better management of patients.
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Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
About this article
Cite this article
Sunil V. Jagtap, Swati S Jagtap, Pranjal Shah, et al./ Leiomyoma with Bizarre Nuclei: An Uncommon Variant of Uterine Smooth
Muscle Neoplasm/Indian Journal of Pathology: Research and Practice 2023;12(3) 105–108.
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
Description: Specimen of pan hysterectomy shows grey white, firm, whorled, circumbscibed tumors with areas of hemorrhages.
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Description: Photomicrograph showing leiomyoma: tumor arranged in a diffuse sheath, whirling patterns having show multifocal bizarre cells. (Haematoxylin & Eosin stain, x10)
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Description: Photomicrograph showing multinucleated bizarre cells that may have a diffuse distribution, prominent nucleoli, and karyorrhectic nuclei. (Hematoxylin & Eosin stain, x100)
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Description: Photomicrograph showing mononucleated or multinucleated bizarre cells in a background of typical leiomyoma. (Haematoxylin & Eosin stain, x100)