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Histopathological Study of Malignant Neoplastic Lesions of Breast

Udasimath Shivakumarswamy, Associate Professor, Department of Pathology, Hassan Institute of Medical Sciences (HIMS), Hassan, Karnataka 573201, India. , Udasimath Shivakumarswamy* , Manasa Das** , Nagesha K.R.***

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Indian Journal of Pathology: Research and Practice 6(4 (Part-1)):p 943-947, Oct-Dec 2017. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6417.18

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Abstract

Breast cancer is a leading cause of mortality and morbidity among women worldwide.The high mortality associated with breast cancer is linked to the aggressiveness of the tumor which depends to a large extent on the histopathological subtypes. It is a heterogeneous disease, comprising multiple entities associated with distinctive histological and biological features, clinical presentations and behaviours and responses to therapy. Histological grade has been incorporated in multiple, validated, prognostic algorithms to determine breast cancer therapy, such as the Nottingham PrognosticIndex. Many studies have tried to identify prognostic factors for breast cancer with nodal status and histopathologic subtypes featuring prominently as prognostic indices. This study was a retrospective analysis of all consecutive breast cancer specimens study from January 2011 to September 2016 biopsysubmitted to the Pathology Department of Hassan Institutional Medical Sciences, Hassan. Prominent histomorphological features, grading, typing, Lymphovascular invasion, lymph node involvement and involvement of the surgical margins were studied in detail. The aim of this study was to know the age incidence patterns for different histopathologic types of carcinoma and to know the involvement of deep resected margin and number of lymph nodes by malignant cells.

Keywords: Breast Cancer; Histopathology Grading; Resected Margin; Nottingham Prognostic Index. 

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.6417.18

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