Abstract

Introduction:  Upper GI diseases (lesions) are frequently seen in clinical practice. These are  associated with mortality and morbidity in patients with GI lesions. Early  diagnosis of inflammatory disorders, infectious diseases, physical, mechanical  and toxic reactions and neoplasms of upper gastrointestinal tract is possible  with endoscopic biopsies with its histopathological correlation.  Materials and methods: This prospective study was carried out on 162  patients in Dr. D.Y. Patil Medical college, Hospital and research centre, Pune  for a period of 2 years from June 2019-2021. Biopsy specimens were fixed in  10% formalin and routinely processed in Haematoxylin & Eosin stain. Results:  A total of 250 biopsy samples were obtained from 162 patients of which  188(75%) were from Stomach, 33 (13%) from Duodenum, 25(10%) from  Esophagus and 2% from gastro esophageal junction. Maximum biopsies were  carried out in the age group of 31-40 years. 149 (64.19%) of biopsies were  from males and 101 (35.8%) were from females. Among the total cases, 140  (86.41%) were non neoplastic lesions whereas 22 (13.58%) were neoplastic  lesions. Epigastric pain seen in 71 (43.8%) was the commonest symptom  ofupper gastrointestinal lesions.  Conclusion: The upper GI endoscopy helps in early detection of several  mucosal lesions, diagnosis of malignancies at early stages and of clinically  suspected lesions leading to prompt treatment.

• 1.   Sandhya PG, Madhusaudan C, NaseenN, Balkrishnan CD, Balagurunathan K. Interpretation of upper gastrointestinal tract endoscopic mucosal biopsies; a studyconducted in teaching hospital in Puducherry, India. International journal of medical and health sciences 2012;1:17-24.
• 2.   MemonF, BalochK, Memon AA. Upper gastro in test in alendoscopic biopsies; morphological spectrum of lesions. ProffesionalMedJ2015; 22:1574-79
• 3.   Lippincott Williams and Wilkins: Gastrointestinal pathology: An Atlas and text. 3rded 2007by Cecilia M. Fenoglio Preiser, AmyE. Noffsinger.p 64-65.
• 4.   Krishnappa R, Horakerappa MS, Mangala Ali Karar, Gouri Mangala. A study of his to pathological spectrum of upper gastrointestinal tract endoscopic biopsies. Int J Medical Res Health Sciences 2013;2: 418-24.
• 5.   International Agency for Research on Cancer. Latest world cancer statistics Global cancer burden rises to 14. 1million new cases in 2012- Marked increase in breast cancers must be addressed. World Health Organization.2013;12:223
• 6.   Shin A, Won YJ, Jung HK, Kong HJ, Jung KW, Oh CM, et al. Trends in incidence and survival of esophageal cancer in Korea- Analysis of the Korea Central Cancer Registry Database. J Gastroenterol Hepatol. 2018;33:1961-1968.
• 7.   Khandelia R, Saikia M. Histopathologic Spectrum of Upper Gastrointestinal Tract Mucosal Biopsies- A Prospective Study. Int J Med Sci Clinic Invent. 2017;4:3314- 3316.
• 8.   Ozturk S, Serinsoz E, Kuzu I, Ensari A, Erden E, Kansu A, et al. The Sydney System in the assessment of gastritis- Inter-observer agreement. The Turkish J Gastroenterol. 2001;12:36-39.
• 9.   Sharma A,Gupta K. Histopathological spectrum of upper gastrointestinal tract endoscopic biopsies in a tertiary care hospital in rural population in north India int. j. of adv. res.2020; 8 :945-950
• 10.   Theresa, JM, M, Gerard J, Rakesh, Basha, KS. Evaluating the spectrum of histomorphological patterns on endoscopic biopsy in patients with upper gastrointestinal tract disorders. Tropical Journal of Pathology and Microbiology. 2020 ;6:1-8.
• 11.   Mohan B, Manjunath H, Geethamani V, Dharani V, Sushma T, Akshatha B Histomorphological Analysis of Upper Gastrointestinal Endoscopic Biopsies: A Retrospective Study of 106 Cases National Journal of Laboratory Medicine.2019;8:04-07.
• 12.   Hirachand, S, Sthapit, RR, Gurung, P, Pradhanang, S ,Thapa, R, Sedhai, M, Regmi, S. Histopathological spectrum of upper gastro in testinalendo scopicbiopsies. Journal of BP Koirala Institute of Health Sciences. 2018;1:67-74
• 13.   Shennak MM, Tarawneh MS, Al Sheik. Upper gastrointestinal diseases in symptomatic Jordanians-A prospective study. Ann Saudi Med. 1997;471-474.
• 14.   Paymaster JC, Sanghvi LD, Ganghadaran P. Cancer of gastrointestinal tract in western India. Cancer 1968; 21:279- 87.
• 15.   Patel K, Nichkaode P, Panchabhai, S Reddy M, Santhan, B Singh C. Evaluation of persistent upper abdominal pain by upper gastrointestinal endoscopy. International Surgery Journal. 2020; 10:2349-2902.
• 16.   Ainapure R, Tanga V. A clinico - endoscopic study of upper GI disorders in ruralpopulation. Inter Surg J. 2018; 5:1111-3.
• 17.   RaniD, BhuvanS, Gupta A, Astudy of morphological spectrum of upper gastrointestinal tract lesions by endoscopy and correlation between endoscopic and histopathologicalfindings. Indian J Pathol Onco l2019; 6:28-34.
• 18.   Kothari SL, Dayal A, Patel SM. Interpretation of Upper Gastro intestinal Tract Mucosal Biopsies –A Tertiary Care Centre Experience. Annals of Pathology and Laboratory Medicine. 2018; 5:709-714.
• 19.   H Ganga, PB Indudhara. Histopathological spectrum of lesions of upper gastrointestinal tract: A study of endoscopic biopsies. International Journal of Clinical and Diagnostic Pathology. 2018: 1;21-25.
• 20.   Malkan G, Mohandas KM. Epidemiology of digestive cancers in India. I. General principles and esophagealcancer. Indian J Gastroenterol 1997; 16:98-102.
• 21.   Samarasam I. Esophageal cancer in India: Current status and future perspectives. IntJAdv Med Health Res 2017;4:5-10
• 22.   Karre S, Jonnalagadda K, Seshagiri T, Gorrela, V. Histopathological spectrum of upper gastrointestinal endoscopic biopsies. Indian Journal of PathologyandOncology.2019: 6; 422- 427
• 23.   Stockbruegger RW. Bacterial over growth as a consequence of reducedgastricacidity. Scand JGastroenterol Suppl.1985; 111:7–16.
• 24.   Suvarna S, Rao P, Pai M. Histomorphologic study of upper gastrointestinal tract endoscopic biopsies with special reference to neoplastic lesions. Med Pulse International Journal of Pathology. September2020; 15(3): 36-39.
• 25.   Kim MJ, Choi SB, Han HJ, Park PJ, Kim WB, Song TJ, Suh SO, Choi SY. Clinicopathological analysis and survival outcome of duodenal adenocarcinoma. Kaohsiung JMed Sci.2014; 30:254-9.

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