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Indian Journal of Pathology: Research and Practice

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Histological Diagnosis of Angiofibroma in Tuberous Sclerosis

Jaisri Ananthapadmanaban , Jaisri Ananthapadmanaban

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Indian Journal of Pathology: Research and Practice 3(2):p 39-41, July - December 2014. | DOI:

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Abstract

Background: A ten year old male child presented with altered behaviour, low intelligence quotient and skin lesions. The child also had respiratory discomfort and palpitations. On investigation, a cardiac rhabdomyoma was located and excised. The skin lesions were ash leaf macules[1], shagreen patches and papulonodular lesions on the face and periungual region on the foot. This combination makes the diagnosis evident as tuberous sclerosis. Methods: Biopsy of the papulonodular lesions were done and histopathology revealed them as angiofibroma (adenoma sebaceum).[2] An angiofibroma by definition is supposed to have proliferation of blood vessels and fibrous tissue on microscopic examination. Results: This angiofibroma had in addition hyperplasia of sebaceous glands. A review of the literature revealed that sebaceous hyperplasia is only a secondary change in an angiofibroma.  Discussion: This case is presented here to highlight the microscopic diagnosis of angiofibroma and to state that sebaceous gland proliferation though a secondary change, can also present in angiofibromas and pathologists need not look for another diagnosis.

Keywords: Angiofibroma; adenoma sebaceum; sebaceous hyperplasia.

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