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Histogenesis of Liver in Human Fetuses

Manirul Islam , Manirul Islam

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Indian Journal of Anatomy 7(3):p 279-284, May-June 2018. | DOI: http://dx.doi.org/10.21088/ija.2320.0022.7318.10

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Abstract

Introduction: The present study attempted to find out the histological changes of liver during its development in human fetuses. Methods: Liver from 10th–40th GW fetuses were studied after staining with Hematoxylin and Eosin, and Masson’s Trichrome stains. Results: The liver from 10th week onwards to term consists of two different cellular elements, larger cells with pale staining centrally located nuclei, hepatocytes and dark staining smaller cells with dark rounded nuclei, the haemopoietic cells. The haemopoietic cells occupy larger area from 10th week onwards till 22nd week when both the elements are equal in quantity, after that hepatocytes quantity increases gradually and the haemopoietic cells decreases in amount and at term only little haemopoietic cells remains. Sinusoids are irregular and having wide lumen from 10th to 18th week, after that the lumen become narrow and regular. Within the sinusoids lies the haemopoietic cells and all the sinusoids are lined by fenestrated endothelium. Hepatic lobules become apparent after 22nd week and kupffer cells appear after 25th week. Bile duct, hepatic artery and portal vein all identified from 14th week onwards till term. Discussion: During early development, liver was composed of collagen fibers with fibroblast cells, hepatocytes and bigger haemopoietic cells. Haemopoietic cells could be detected till 36th GW fetuses. Even though immature RBCs and haemopoietic stem cells were detected, hemopoiesis in the liver along with it hepatocytes could be ascertained in the present study.

 

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DOI: http://dx.doi.org/10.21088/ija.2320.0022.7318.10

Keywords

Haemopoietic Cells; Hepatocytes; Kupffer Cell; Stem Cell; Haemopoiesis.

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