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Indian Journal of Forensic Medicine and Pathology 10(3):p 242-244, Jul-Sep 2017. | DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.10317.13
Case Report
Hepatocellular Carcinoma- Sarcomatoid Variant: A Rare Occurence
Vani Dayanand, Rao Srijana S.P., Pushpa H.R., Bharathi M.
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Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Indian Journal of Forensic Medicine and Pathology 10(3):p 242-244, Jul-Sep 2017. | DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.10317.13
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Timeline
Received : July 22, 2017
Accepted : August 16, 2017
Published : September 30, 2017
Abstract
Background: Primary liver cancer is the second most common cancer in Asia, hepatocellular carcinoma being the most common histological type. Hepatocellular carcinoma with sarcomatoid features and osteoclast like giant cells is a rare malignancy and has higher risk of metastasis as compared to usual Hepatocellular carcinoma. Case Description: We recently encountered an autopsy case of cirrhotic liver with sarcomatoid variant of Hepatocellular carcinoma in a 59 year old male. Macroscopically, it presented as a grey white to grey yellow ill defined nodule with central necrosis and surrounding micronodular cirrhotic changes. Microscopically, tumor predominantly composed of two cell types were noticed- classical hepatocellular carcinoma with atypical hepatocytes and pleomorphic spindle cells with frequent mitosis and multinucleated giant cells. As the tumor had both epithelial and mesenchymal differentiation in the same lesion, the diagnosis of sarcomatoid variant of hepatocellular carcinoma was made. Literature Review: Sarcomatoid variant of carcinoma has to have both epithelial and mesenchymal differentiation in the same lesion. Occasionally when the tumor is fully composed of malignant spindle cells, it is difficult to distinguish from various primary sarcomas and has to be confirmed by immunohistochemical staining Clinical relevance: The prognosis of the sarcomatoid variant of Hepatocellular carcinoma is unfavourable compared with classical Hepatocellular carcinoma which could be attributed to aggressive intrahepatic spreading and frequent metastasis. Histopathological study is the only effective diagnostic tool for confirmation.
References
- 1. Bosman FT, Carneiro F, Hruban RH, Theise ND. WHO classification of Tumours of the Digestive System. Lyon: IARC, 2010.
- 2. Han JH, Park YN, Jung WH, Chi HS, Park C. A case with sarcomatoid Hepatocellular Carcinoma.Yonsei Medical Journal, 1998;39(4):390394.
- 3. Kyoung Bun Lee. Sarcomatoid hepatocellular carcinoma with mixed osteoclast like giant cells and chondroid differentiation. Clinical and molecular Hepatology Sept 2014;20(3):313316.
- 4. Hans Helmut Dahm. Immunohistochemical evaluation of a sarcomatoid hepatocellular carcinoma with osteoclast like giant cells. Dahm diagnostic pathology, 2015;10:40:pp17.
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Cite this article
Licence:
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
| Received | Accepted | Published |
|---|---|---|
| July 22, 2017 | August 16, 2017 | September 30, 2017 |
DOI: http://dx.doi.org/10.21088/ijfmp.0974.3383.10317.13
Keywords
Hepatocellular CarcinomaSarcomatoidOsteoclast Like Giant CellsSearch for Similar Articles
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Timeline
| Received | July 22, 2017 |
| Accepted | August 16, 2017 |
| Published | September 30, 2017 |
licence
Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
