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Purini PY, Raghava A, Sharmila V, et al. Granulosa cell tumor of the ovary: a rare case report and review of literature. Indian J Obstet Gynecol. 2024;12(4):175-9.
Timeline
Received : November 25, 2024
Accepted : December 18, 2024
Published : December 29, 2024
Abstract
Granulosa cell tumors (GCTs) are uncommon ovarian neoplasms that account for 2% 5% of ovarian malignancies. GCTs are of two types; one is the adult type seen among peri menopausal women and another is juvenile type seen among prepubertal girls and in women aged less than 30 years of age. Adult granulosa cell tumors are more commoner than juvenile type. We present a case of GCTs of the ovary in post-menopausal women who presented to us with post-menopausal bleeding. On further evaluation, a solid mass is noted in the right ovary. Endometrial biopsy revealed disordered proliferative endometrium. She underwent staging laparotomy, and Intraoperatively, the right ovary is replaced with a 10x8 cm solid mass and capsular breech is noted. Histopathology of the specimen revealed a Granulosa cell tumor, stage IC2. Postoperatively, she received adjuvant chemotherapy with Carboplatin and Paclitaxel for 6 cycles and she is under follow-up.
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Purini PY, Raghava A, Sharmila V, et al. Granulosa cell tumor of the ovary: a rare case report and review of literature. Indian J Obstet Gynecol. 2024;12(4):175-9.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.
Image of gross specimen showing uterus with right solid ovarian mass, left ovary is atrophic, bilateral tubes and omentum appears normal
Description: No description available.
Image showing cut section of enlarged uterus and ovarian mass
Description: No description available.
: Image showing cut section of the granulosa cell tumor of the ovary in which predominantly solid areas with very few cystic areas are seen
Description: No description available.
HPE image showing the tumor cells arranged in diffuse, trabecular, insular and macrofollicular growth patterns with intervening stroma
Description: No description available.
Microfollicular pattern (call-exner bodies)
Description: No description available.
Oil immersion view (100x) to highlight the nuclear grooves. The tumor cells having round to oval nuclei, irregular nuclear membranes and scant cytoplasm. Mitosis is low