Abstract

Sickle cell anaemia (SCA) is a prevalent haemoglobinopathy worldwide, with Gujarat exhibiting a notably high prevalence. This study focuses on the frequency and genotype distribution of SCA within the tribal community of Dahod, aiming to enhance public health outcomes and contribute to a sickle cell-free India. Study conducted at a tertiary care hospital, it analyses data from 12,259 individuals during June 2024 to August 2024. The findings reveal a 17.15% prevalence of SCA among the tribal community. Among HbS positive individuals, SCT-AS genotype was observed in 14.55% of cases, while the SCD HbSb0thal genotype was noted in 2.61% of cases. The frequency of SCT Hb-AS is approximately 5.6 times higher than that of SCD HbSb0thal among the HbS-positive tribal population. Additionally, a gender disparity was observed, with a higher frequency in females.

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