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Evaluation of Teratogenic Potential of Ondansetron on Developing Chick Embryo

Bokariya P.* , Bokariya P.* , Kothari R.** , Gujar V.* , Shende MR*** , Doshi MA***

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Indian Journal of Anatomy 5(3):p 321-328, Sept - Dec 2016. | DOI: DOI: http://dx.doi.org/10.21088/ija.2320.0022.5316.22

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Abstract

 Objective: To determine the teratogenic potential on developing chick embryo after injection of ondansetronto the fertilised egg and comparing it withembryos of controls. Methodology: The present study was conducted inthe Department of Anatomy in our Institute.Fertilised chicken eggs were exposed toondansetron by injecting the drug through air sac on 3rd Embryonic Day (ED). The control group and the experimental group were examined intermittently by candling method to check death of embryos. Survived Chicken eggs were dissected out on day 19th of incubation and were carefully observed for any major congenital abnormalities. The embryos thus dissected out were subjected to estimation of crown-rump length (CRL), changes in weight of egg (before and after incubation), volume of embryos. Results:The mortality in experimental group was significantly higher as compare to control ones. All the other parameters studied in this study are non-significant statistically. Conclusion: The outcome of study is suggestive of no significant effect on various parameters used to evaluate teratogenicity but significant mortality is sign of concern.

Keywords: Chick Embryo; Ondansetron; Teratogen; Mortality

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DOI: DOI: http://dx.doi.org/10.21088/ija.2320.0022.5316.22

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