Full Text (PDF)
Review Article

Dengue Virus: A Human Threat: Review of Literature

Lavanya J, Swarroprani N.B., Pooja Rao, Lohith Kumar R

Author Information

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. 


RFP Journal of Hospital Administration 9(1):p 17-23, Jan-June 2025. | DOI: 10.21088/jha.2582-3566.9125.2

How Cite This Article:

Lavanya J, Swarroprani N.B., Pooja Rao et. al, Dengue Virus-A Human Threat: Review of Literature. RFP Jr. of Hosp. Admin.; 2025 9(1): 17-23.

Timeline

Received : January 31, 2025         Accepted : June 16, 2025          Published : June 30, 2025

Abstract

Most Rapidly spreading arboviral infection across various states of our country is Dengue Fever. It is spread by Aedes aegypti mosquito which harbors Dengue virus, which is a RNA virus belonging to family Flaviviridae. The patient affected by Dengue presents with asymptomatic infection to complications like Dengue haemorrhagic fever and Dengue Shock Syndrome. Most common manifestations include high fever of acute onset, muscle and joint pain, cutaneous rash, myalgia, hemorrhagic episodesand circulatory rash. Early and accurate diagnosis is critical to reduce mortality.


References

  • 1.   National Institute of Health. Available at https: //www.niaid.nih.gov/diseases-conditions/ dengue-fever.
  • 2.   Gupta N, Srivastava S Jain A, Chaturvedi UC. Dengue in India. Indian Journal of Medical Research 2012; 136; 373-90.
  • 3.   Geneva Switzerland: WHO 2009, WHO. Dengue: Guidelines for diagnosis, Treatment, Prevention and Control. Part 1.1.6: Dengue case classification; pp. 10-2.
  • 4.   (Waterman SH, Gubler DJ, Dengue fever. Clinical Dermatology. 1989; 7;117-22.).
  • 5.   (Gubler DJ. Dengue and dengue Hemorrhagic fever. Clin Microbiol Rev. 1998;11:480–96.
  • 6.   (Ahmed FU, Mahmood CB, Sharma JD, Hoque SM, Zaman R, Hasan MH. Dengue fever and dengue haemorrhagic fever in chidren the 2000 out break in Chittatong, Bangladesh. Dengue Bulletin. 2001;25:33–9.
  • 7.   (National Institute of Communicable Diseases. Investigation and Control of Outbreaks: Dengue and Dengue Hemorrhagic Fever. 1997.
  • 8.   Gurugama P, Garg P, Perera J, Wijewickrama A, Seneviratne SL. Dengue viral infections. Indian J Dermatol. 2010;55(1):68–78. doi: 10.4103/0019-5154.60357.
  • 9.   Shivpuri A, Shivpuri A. Dengue – An over view. Dent Med Probl. 2011;48(2):153–6.
  • 10.   Darvin Scott Smith et al, Dengue Differential Diagnoses. MedscapeUpdated: Dec 14, 2024.
  • 11.   Chaterji S, Allen JC Jr, Chow A, Leo YS, Ooi EE. Evaluation of the NS1 rapid test and the WHO dengue classification schemes for use as bedside diagnosis of acute dengue fever in adults. Am J Trop Med Hyg. 2011 Feb. 84(2):224-8.
  • 12.   Potts JA, Rothman AL. Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations. Trop Med Int Health. 2008 Nov. 13(11):1328-40.
  • 13.   (Bottieau E, Clerinx J, Van den Enden E, Van Esbroeck M, Colebunders R, Van Gompel A. Fever after a stay in the tropics: diagnostic predictors of the leading tropical conditions. Medicine (Baltimore). 2007 Jan. 86(1):18-25.
  • 14.   Guideline CDC. Clinical Testing Guidance for Dengue. Centers for Disease Control and Prevention. Available at https://www.cdc. gov/dengue/hcp/diagnosis-testing. August 26, 2024; Accessed: December 14, 2024.
  • 15.   Malhotra N, Chanana C, Kumar S. Dengue infection in pregnancy. Int J Gynaecol Obstet. 2006 Aug. 94(2):131-2.
  • 16.   A. Rather, H.A. Parray, J.B. Lone, W.K. Paek J. Lim, V.K. Bajpai, Y.H. Park Prevention and control strategies to counter dengue virus infection Front. Cell. Infect. Microbiol., 7 (2017), p. 336.
  • 17.   W.H. Wang, A.N. Urbina, M.R. Chang, W. Assavalapsakul, P.L. Lu, Y.H. Chen, S.F. Wang. Dengue hemorrhagic fever–a systemic literature review of current perspectives on pathogenesis, prevention and control. J. Microbiol. Immunol. Infect., 53 (6) (2020), pp. 963-978.
  • 18.   T. Pang, T.K. Mak, D.J. Gubler. Prevention and control of dengue—the light at the end of the tunnel. Lancet Infect. Dis., 17 (3) (2017), pp. e79-e87
  • 19.   A. Abidemi, N.A. Aziz. Optimal control strategies for dengue fever spread in Johor,Malaysia. Comput. Methods Prog. Biomed., 196 (2020), Article 105585.
  • 20.   W.H. Wang, A.N. Urbina, M.R. Chang, W. Assavalapsakul, P.L. Lu, Y.H. Chen, S.F. Wang Dengue hemorrhagic fever–a systemic literature review of current perspectives on pathogenesis, prevention and control J. Microbiol. Immunol. Infect., 53 (6) (2020), pp. 963-978.
  • 21.   H.J. Kuo, K. Lee, J.W. Liu Analyses of clinical and laboratory characteristics of dengue adults at their hospital presentations based on the World Health Organization clinical-phase framework: emphasizing risk of severe dengue in the elderly J. Microbiol. Immunol. Infect., 51 (6) (2018), pp. 740-748
  • 22.   L.C. Katzelnick, L. Gresh, M.E. Halloran, J.C. Mercado, G. Kuan, A. Gordon, A. Balmaseda, E. Harris Antibody-dependent enhancement of severe dengue disease in humans Science, 358 (6365) (2017), pp. 929-932.
  • 23.   S.B. Halstead, S. Mahalingam, M.A. Marovich, S. Ubol, D.M. Mosser Intrinsic antibodydependent enhancement of microbial infection in macrophages: disease regulation by immune complexes Lancet Infect. Dis., 10 (10) (2010), pp. 712-722.
  • 24.   S.R. Hadinegoro, J.L. ArredondoGarcía, M.R. Capeding, C. Deseda, T. Chotpitayasunondh, R. Dietze, Hj Muhammad Ismail, H.I., Reynales, H., Limkittikul, K., Rivera-Medina, D.M. and Tran, H.N. Efficacy and long-term safety of a dengue vaccine in regions of endemic disease N. Engl. J. Med., 373 (13) (2015), pp. 1195-1206..
  • 25.   M. Aguiar, N. Stollenwerk, S.B. Halstead The impact of the newly licensed dengue vaccine in endemic countries PLoS Negl. Trop. Dis., 10 (12) (2016), Article e0005179.
  • 26.   X. Yang, M.B. Quam, T. Zhang, S. Sang Global burden for dengue and the evolving pattern in the past 30 years J. Travel Med., 28 (8) (2021).
  • 27.   A. Wilder-Smith TAK-003 dengue vaccine as a new tool to mitigate dengue in countries with a high disease burden Lancet Glob. Health, 12 (2) (2024), pp. e179-e180.
  • 28.   E.G. Kallás, M.A. Cintra, J.A. Moreira, E.G. Patiño, P.E. Braga, J.C. Tenório, V. Infante, R. Palacios, M.V.G. de Lacerda, D. Batista Pereira, A.J. da Fonseca Live, attenuated, tetravalent Butantan–Dengue vaccine in children and adults New England J. Med., 390 (5) (2024), pp. 397-408.
  • 29.   E. Prompetchara, C. Ketloy, S.J. Thomas, K. Ruxrungtham Dengue vaccine: Global development update Asian Pac. J. Allergy Immunol., 38 (3) (2020), pp. 178-185.
  • 30.   C.H. Huang, Y.T. Tsai, S.F. Wang, W.H. Wang, Y.H. Chen Dengue vaccine: an update Expert Rev. Anti-Infect. Ther., 19 (12) (2021), pp. 1495- 1502 ).
  • 31.   W.H.O.I. Dengue Guidelines for diagnosis, treatment Prev. Control., No Title (2009).
  • 32.   V. Kamath, A.B. Aishwarya Dengue vaccines: current status and future perspectives APIK J. Int. Med. (2024), pp. 10-4103.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This systematic review does not involve human or animal participants; ethics approval was waived.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

No conflicts of interest.


About this article


Cite this article

Lavanya J, Swarroprani N.B., Pooja Rao et. al, Dengue Virus-A Human Threat: Review of Literature. RFP Jr. of Hosp. Admin.; 2025 9(1): 17-23.


Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. 


Received Accepted Published
January 31, 2025 June 16, 2025 June 30, 2025

DOI: 10.21088/jha.2582-3566.9125.2

Keywords

DengueDengue hemorrhagic feverDengue shock syndromeRNA VirusSterile insect techniqueDengvaxia

Article Level Metrics

Last Updated

Monday 26 January 2026, 19:22:52 (IST)


162

Accesses

7
40
00

Citations


NA
NA
NA

Download citation


Article Keywords


Keyword Highlighting

Highlight selected keywords in the article text.


Timeline


Received January 31, 2025
Accepted June 16, 2025
Published June 30, 2025

licence


Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator. 


Access this article



Share