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Corona Virus Disease-19 Obesity & Leptin: A Complex Paradigm

Jitender Gairolla , Diksha1 , Shikha Mudgal2 , Prakamya Gupta3 , Pratima Gupta4 , Manisha Naithani5 , Yogendra Pratap Mathuria6 , Priyanka Naithani7 , Biswajeet Sahoo8 , Mankirat Kaur Sachdeva9 , Jitender Gairolla10

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Journal of Microbiology and Related Research 7(2):p 65-74, July-December 2021. | DOI: http://dx.doi.org/10.21088/jmrr.2395.6623.7121.5

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Diksha Rani, Jitender Gairolla, Shikha Mudgal, et. al./Corona Virus Disease-19, Obesity & Leptin: A Complex Paradigm/J Microbiol Relat Res. 2021;7(2): 65–74
 

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Abstract

The global prevalence of obesity is increasing and recognized as a potential risk factor for viral infections including Coronavirus Disease-19. Morbidity and mortality due to COVID-19 are higher in obesity which is considered a constant state of low-grade inflammatory milieu. Emerging data revealed a fatal connection of obesity with COVID-19 however the underlying mechanism is unclear. Leptin, a non-glycosylated peptide hormone derived from white adipose tissue that assists in metabolism, homeostasis, neuroendocrine, and other physiological functions. Additionally, leptin, as an adipocytokine has pro-inflammatory properties and acts as a connecting link between obesity and host immune responses thus, proliferates the secretion of C-reactive protein (CRP), IFN-γ, TNF-α IL-6, IL-4 and IL-2. This paper aims to address the paramount role of leptin as a potential mediator of inflammation that could exaggerate and worsen the prognosis of COVID-19 in obese individuals. Furthermore, the disproportionate efficacy of the COVID-19 vaccine in obese individuals is also highlighted.

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Diksha Rani, Jitender Gairolla, Shikha Mudgal, et. al./Corona Virus Disease-19, Obesity & Leptin: A Complex Paradigm/J Microbiol Relat Res. 2021;7(2): 65–74
 

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DOI: http://dx.doi.org/10.21088/jmrr.2395.6623.7121.5

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