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Contribution of Barbara Mcclintock in Field of Pediatrics

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Pediatric Education and Research 13(2 (Special Supplement -I)):p 90-92, July-December 2025. | DOI: 10.21088/per.2321.1644.13225.4

How Cite This Article:

Kasumbiwal Ajay H., Male Rohit H., Varsha Dope, et al. Contribution of Soumya Swaminathan in Field of Pediatrics. Pediatr. Edu. Res. 2025; 13(2): 90-92.

Timeline

Received : November 24, 2025         Accepted : December 28, 2025          Published : December 30, 2025

Abstract

Barbara McClintock was a pioneering geneticist whose discoveries fundamentally reshaped the understanding of heredity and genome regulation. Her work on maize cytogenetics led to the groundbreaking discovery of transposable elements, demonstrating that genes are capable of moving within and between chromosomes. This insight revealed that the genome is dynamic rather than fixed, introducing new perspectives on gene expression, developmental regulation, and genomic instability. Although McClintock did not directly work in Pediatrics, her findings form the basis of modern interpretations of congenital anomalies, chromosomal rearrangements, and single-gene disorders affecting children. Her scientific career was marked by significant challenges, including gender bias and delayed recognition, yet she maintained remarkable intellectual independence. Her contributions were eventually honoured with the Nobel Prize in Physiology or Medicine in nineteen eighty-three. McClintock’s legacy continues to influence developmental biology, clinical genetics, and Pediatric diagnostics, highlighting the enduring relevance of curiosity, perseverance, and scientific integrity. Key Message:Barbara McClintock’s discovery of transposable elements transformed the understanding of genome behaviour and laid essential foundations for modern developmental and Pediatric genetics. Her work demonstrates how curiosity, resilience, and scientific independence can drive breakthroughs that continue to influence clinical practice and genetic research.

References

  • 1.   Encyclopaedia Britannica. Barbara McClintock.
  • 2.   National Library of Medicine (NIH). Profiles in Science – Barbara McClintock.
  • 3.   Nelson Textbook of Pediatrics.
  • 4.   Essentials of Pediatrics.
  • 5.   Pediatric Clinical Examination.
  • 6.   Keller E.F. A Feeling for the Organism: The Life and Work of Barbara McClintock. W.H. Freeman; 1983.
  • 7.   Fedoroff N.V. McClintock’s Challenge in the Twenty-First Century. Science.
  • 8.   Lisch D. How Important Are Transposons for Plant Evolution? Nature Reviews Genetics.

Data Sharing Statement

There are no additional data available. All raw data and code are available upon request.

Funding

This research received no funding.

Author Contributions

All authors contributed significantly to the work and approve its publication.

Ethics Declaration

This article does not involve any human or animal subjects, and therefore does not require ethics approval.

Acknowledgements

We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.

Conflicts of Interest

The authors report no conflicts of interest in this work.

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Cite this article

Kasumbiwal Ajay H., Male Rohit H., Varsha Dope, et al. Contribution of Soumya Swaminathan in Field of Pediatrics. Pediatr. Edu. Res. 2025; 13(2): 90-92.

Licence:

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.

Received Accepted Published
November 24, 2025 December 28, 2025 December 30, 2025
DOI: 10.21088/per.2321.1644.13225.4

Keywords

Transposable elementsGene regulationDevelopmental geneticsPediatric genetic disorders

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Timeline

Received November 24, 2025
Accepted December 28, 2025
Published December 30, 2025

licence

Attribution-Non-commercial 4.0 International (CC BY-NC 4.0)

This license enables reusers to distribute, remix, adapt, and build upon the material in any medium or format for noncommercial purposes only, and only so long as attribution is given to the creator.


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