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Comparative Evaluation of Metformin and Letrozole in a Rat Model of Polycystic Ovary SyndromeComparative Evaluation of Metformin and Letrozole in a Rat Model of Polycystic Ovary Syndrome

Pratip Chakraborty , Chakraborty Pratip1 , Chatterjee Sujan2 , Ipsita Chaterjee3 , Patra Debajyoti4 , Chakravarty Baidyanath5 , Kabir Syed N

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Indian Journal of Diabetes and Endocrinology 1(1):p 19-27, January - June 2019. | DOI:

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Chakraborty Pratip, Chatterjee Sujan, Ipsita Chaterjee. Comparative Evaluation of Metformin and Letrozole in a Rat Model of  Polycystic Ovary Syndrome. Indian Journal of Diabetes and Endocrinology. 2019;1(1):19-27.

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Received : N/A         Accepted : N/A          Published : N/A

Abstract

Background: A number of rat models have  been proposed to investigate the heterogeneity  of polycystic ovary syndrome (PCOS), hyperandrogenized routine being the most popular one.  Although, effects of androgen excess have been  widely investigated, the ameliorating potential of  the ovulogens on different aspects of the treatment  on a single model is yet to be explored. Aims: This  particular experimental study ends to investigate the  effects of metformin and letrozole on experimentally  induced rodent model of PCOS. Methods and materials: After neonatal androgenisation (1.5 mg/animal), rats  were given metformin (200 mg/kg body weight for  4 weeks) or letrozole (0.5 mg /kg/day for 15 days)  from ~53 day of age. Ovarian histology, response to  exogenous gonadotropins, hormonal profile, glucose  tolerance, and dyslipidaemic features with RTPCR of specific steroidogenic and hyperinsulinemic  genes were carried out to compare and evaluate  the therapeutic response of the drugs. Results  and conclusion: Androgenized rats had polycystic  ovaries characterized by increased theca interna  and fewer or no functional corpora lutea. Metformin  improved ovarian responses and was superior in  attenuating testosterone status, hyperinsulinemia, dyslipidaemia along with a significant improvement  in expression of the genes assessed. In conclusion,  metformin reverted the hyperinsulinemia-associated  hyperandrogenemia to reinstate ovulatory function  with parallel improvements in the metabolic corners  of the syndrome; however, letrozole appears to have  no beneficial effect with reference to restoration  of ovulation or amelioration of polycystic state of  the ovary.

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Chakraborty Pratip, Chatterjee Sujan, Ipsita Chaterjee. Comparative Evaluation of Metformin and Letrozole in a Rat Model of  Polycystic Ovary Syndrome. Indian Journal of Diabetes and Endocrinology. 2019;1(1):19-27.

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Keywords

polycystic ovary syndrome; ovulation induction; hyperinsulinemia; hyperandrogenemia; animal model.

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