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Coagulation Profile in Pregnancy Induced Hypertension to Predict DIC and HELLP Syndrome

Sonal Saxena. , Siddhartha Shanker Sinha1 , Vikas Mishra2 , Sonal Saxena3 , Shashank Shekher Sinha4 , Yogesh Yadav5

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Indian Journal of Pathology: Research and Practice 9(2 (Part-II)):p 165-171, May-August 2020. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.9220.27

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Siddhartha Shanker Sinha, Vikas Misra, Sonal Saxena, Shashank Shekher Sinha, Yogesh Yadav. Coagulation Profile in Pregnancy Induced Hypertension to Predict DIC and HELLP Syndrome. Indian J
Pathol Res Pract 2020;9(2 Part II):165–171.
 

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Abstract

Background and Aim: Hypertensive disorders of pregnancy commonly known as Pregnancy Induced Hypertension (PIH), affects about 10% of all pregnant women around the world. A variety of haematological abnormalities may occur in women with PIH, thrombocytopenia being the most common. There is also a definite exaggeration of the
hypercoagulable state during PIH due to increase in coagulation factors like fibrinogen. A strong relationship exists between the two most important causes of maternal mortality and morbidity worldwide: Preeclampsia and Postpartum haemorrhage. The aim of this study was to find out the changes that occur in the coagulation profile and
platelet indices in PIH as compared to that in normal pregnancy and if they can be used as a reliable indicator of the onset and severity of Disseminated Intravascular Coagulopathy (DIC) and HELLP Syndrome.Method: A total of hundred pregnant women (50 PIH and 50 control) within the age group of 18 to 35 years after 20 weeks period of
gestation were admitted in the antenatal ward of the Department of Obstetrics and Gynaecology of Index Medical College, Indore. Their complete blood picture with platelets count and coagulation profile were done to compare with normal control pregnant women. Result: Bleeding time (BT), Clotting time (CT), one stage Prothrombin time
(PT), activated partial Thromboplastin time (aPTT) and Thrombin time (TT) was significantly higher amongst cases
than in controls. Conclusion:Thus, authors came to the conclusion that platelet indices and coagulation profile canbe used as a reliable early indicator of onset and severity of DIC and HELLP Syndrome.

Keywords: Pregnancy induced hypertension; coagulation profile; Disseminated Intravascular Coagulopathy; HELLP Syndrome.
 

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Siddhartha Shanker Sinha, Vikas Misra, Sonal Saxena, Shashank Shekher Sinha, Yogesh Yadav. Coagulation Profile in Pregnancy Induced Hypertension to Predict DIC and HELLP Syndrome. Indian J
Pathol Res Pract 2020;9(2 Part II):165–171.
 

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.9220.27

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