Afreen Amir Pathan Junior resident, Department of Pathology, Dr. Shankarrao Chavan Government Medical College & Hospital, Nanded 431606, Maharastra, India
Mohammed Abdul Sameer Professor and Head, Department of Pathology, Dr. Shankarrao Chavan Government Medical College & Hospital, Nanded 431606, Maharastra, India
Deepak Sadhu ssistant Professor, Department of Pathology, Dr. Shankarrao Chavan Government Medical College & Hospital, Nanded 431606, Maharastra, India
Address for correspondence: Afreen Amir Pathan, Junior resident, Department of Pathology, Dr. Shankarrao Chavan Government Medical College & Hospital, Nanded 431606, Maharastra, India E-mail: dr.afreen93@gmail.com
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
Afreen Amir Pathan, Mohammed Abdul Sameer, Deepak Sadhu. Clinicohistopathological Spectrum of Adult Renal Tumours:
3yrs Retrospective Study at a Tertiary Care Centre. Ind Jr of Path: Res and Practice 2024;13(1) 07-12.
Timeline
Received : March 02, 2024
Accepted : March 15, 2024
Published : March 30, 2024
Abstract
Background: The broad range of kidney neoplastic lesions that are classified as primary renal tumours includes patterns that are comparatively different in children and adults. Both benign and malignant primary renal tumours are possible. These neoplasms account for two to three percent of all adult malignancies and 80–85% of all primary malignant neoplasms of kidney. Aim and Objective: Finding relative frequencies of various adult renal tumours and examining clinicohistopathological features and their variations in patients under study are goals of this research. Methods: This retrospective investigation was carried out at tertiary care facility on all patients who were diagnosed with kidney tumour based on histology between 2020 and 22. Information was gathered about clinical presentation, pathological features, and demographics of patients. Histological section employed standard haematoxylin and eosin stain for pathological investigation. Results: Over period of three years, among 50 patients, 63% were males and 37% females. Most tumours were malignant: 88% vs. 12% benign. Peak incidence was found more in 6-7th decade. Renal cell carcinoma (RCC) was most prevalent type of cancerous tumour. Angiomyolipoma, oncocytoma, and adult cystic nephroma were examples of benign renal tumours. Discussion: This is single center study from tertiary care center. Range of adult renal tumours found in this study is in line with earlier research findings. We identified both benign and malignant tumours in our investigation. Conclusion: With a thorough literature analysis and focus on each tumour category, this article provides an overview of range of adult renal tumours in tertiary care centres.
References
1. Bray F, Ferlay J, Soerjomataram I, Siegel RL, Torre LA, Jemal A: Global cancer statistics 2018: GLOBOCANestimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J Clin. 2018,68:394-424. 10.3322/caac.21492.
2. Kidney cancer rates are increasing, so what’s fuelling the surge?. (2017).https://news.cancerresearchuk.org/2017/04/24/kidney-cancerrates-are-increasing-so-whats-fuelling-the-surge.
3. Znaor A, Lortet-Tieulent J, Laversanne M, Jemal A, Bray F.International variations and trends in renal cell carcinomaincidence and mortality. EurUrol2015;67:519-30.
4. Sirjuesingh D, Sandy R, Persaud S A (August 27, 2021) Clinicopathological Profile of Renal Cancer in a Caribbean Hospital: Analysis of a SurgicalCase Series. Cureus 13(8): e17482. DOI 10.7759/cureus.17482.
5. Lipworth L, Tarone RE, McLaughlin JK. The epidemiology of renal cell carcinoma. J Urol 2006; Afreen Amir Pathan, Mohammed Abdul Sameer, Deepak Sadhu. Clinicohistopathological Spectrum of Adult Renal Tumours: 3yrs Retrospective Study at a Tertiary Care Centre. 176(6Pt): 2353-2358.
6. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Murray T, Thun MJ. Cancer statistic 2008. CA Cancer J Clin 2008;58(2): 71-96.
7. Abdulmalik M.s.Tayib.Renal Tumors in Adults: The Clinical Experience of 124 Patients. JKAU:Med. Sci.,Vol.18No.1, pp:15-22(2011 A.D./1432 A.H.). DOI:10.4197/Med.18-1.2.
8. Jemal A, Siegel R, Ward E, Hao Y, Xu J, Thun MJ. Cancer statistic 2009. CA Cancer J Clin 2009;59(4): 225-249.
9. Pantuck AJ, Zisman A, Beldegrun AS. The changing naturalhistory of renal cell carcinoma. J Urol 2001; 166: 1611-23
10. Chow WH, Devesa SS, Warren JL, Fraumeni Jr JF. Risingincidence of renal cell cancer in the United States. JAMA1999; 281: 1628-31.
11. Bayapa R. Narapureddy, Narayana R. Konadula, Pallavi Madithati, Nagarjuna R. Narapureddy et al.A Study of the epidemiologic distribution of renal tumors in Tirupati, Andhra Pradesh.Jornal of Dr. NTR University of Health Sciences 2012:1(4):12-16.
12. Alpers CE. The Kidney. In: Kumar V, Abbas AK, Fausto N,Aster JC, editors. Robbins and Cotran pathologic basis of disease.8th ed. Philadelphia: WB Saunders; 2010. p. 905-70.
13. 13.Konnak JW, Grossman HB. Renal cell carcinoma as an incidental finding.JUrol 1985;134:1094-6.
14. Ueda T, Mihara Y. Incidental detection of renal cell carcinoma during radiological imaging. Br J Urol1987;59:513-5.
16. Bretheau D, Lechevallier E, Eghazarian C, Grisoni V, CoulangeC.Prognostic significance of incidental renal cell carcinoma. EurUrol1995;27:319-23.
17. Jayson M, Sanders H. Increased incidence of serendipitously discovered renal cell carcinoma. Urology 1998;51:203-5.
18. Luciani LG, Cestari R, Tallarigo C. Incidental renal cell carcinoma-age and stage characterization and clinical implications: study of 1092patients (1982-1997). Urology 2000;56:58-62.
19. Leslie JA, Prihoda T, Thompson IM. Serendipitous renal cell carcinoma in the post-CT era: continued evidence in improved outcomes. UrolOncol2003;21:39-44.
Data Sharing Statement
There are no additional data available. All raw data and code are available upon request.
Funding
This research received no funding.
Author Contributions
All authors contributed significantly to the work and approve its publication.
Ethics Declaration
This article does not involve any human or animal subjects, and therefore does not require ethics approval.
Acknowledgements
We would like to express our gratitude to the patients, their families, and all those who have contributed to this study.
Conflicts of Interest
No conflicts of interest in this work.
About this article
Cite this article
Afreen Amir Pathan, Mohammed Abdul Sameer, Deepak Sadhu. Clinicohistopathological Spectrum of Adult Renal Tumours:
3yrs Retrospective Study at a Tertiary Care Centre. Ind Jr of Path: Res and Practice 2024;13(1) 07-12.
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
This license
enables reusers to distribute, remix, adapt, and build upon the material in any
medium or format for noncommercial purposes only, and only so long as
attribution is given to the creator.
Description: Photo (a) on 10X and (b) on 40X: Clear cell carcinoma-showing typically compact nests and sheets of cells with clear cytoplasm and distinct membrane.
Heading
Description: Photo. (c) on 10X and (d) on 40X: Transitional cell carcinoma showing neoplastic cells arranged in irregular nests and single with nuclear pleomorphism, hyperchromasia