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Assessing the Prognostic Importance of ER, PR Expression in Meningiomas by Comparing with Proliferative Rate Using Ki67

V. Shanthi , Vissa Shanthi* , Bhavana Grandhi** , Nandam Mohan Rao*** , Byna Syam Sundar Rao*** , Vijaya Lakshmi Muram Reddy**

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Indian Journal of Pathology: Research and Practice 6(2 (Part-2)):p 431-434, APRIL - JUNE 2017. | DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.62(pt-II)17.16

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Abstract

Background: Meningiomas are common brain tumors which are mostly benign and recur frequently. These tumors exhibit steroid hormone receptors which are related to the behavior of the tumor. Aim: To conduct a retrospective study to evaluate the presence of progesterone and estrogen receptors in meningiomas and to correlate their expression with expression of proliferative marker Ki67. Materials and Methods: 24 cases of meningiomas were studied immunohistochemically to detect the expression of ER,PR and Ki67. Other parameters like age and sex were also analyzed. Results: 24 Cases were analyzed and all of them were ER negative. 3 cases were strongly positive, 16 cases were moderately positive and 5 cases were weakly positive for PR immunoreactivity. 3 cases showed moderate positivity, 13 cases were weakly positive and 8 were negative for Ki67. 2 cases of atypical meningioma and 1 case of meningothelial meningioma showed moderate positivity with Ki67and weak positivity with PR immunostaining. Most of these tumors were in the age group of 40-50 years and were seen in females. Conclusion: Tumors with increased PR expression had decreased proliferative rate when compared to tumors with increased Ki67 and decreased PR expression indicating that
PR expression is better prognostic marker for these tumors.

Keywords: Meningioma; Progesterone; Estrogen Receptors; Proliferative Marker Ki67.

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DOI: http://dx.doi.org/10.21088/ijprp.2278.148X.62(pt-II)17.16

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